In the present study, the antibacterial activity effect of methanolic root extracts of Euphorbia Condylocarpa was evaluated against five Gram positive, three Gram negative bacterial strains. The antibacterial activity was determined by agar disk diffusion method. The most susceptible bacteria to Euphorbia Condylocarpa root extracts were Bacillus subtillis, B. pumilis and Staphylococcus epidermidis and displayed larger inhibition zones than Gram negative bacteria. Minimum inhibition concentrations (MIC) of extract against these bacteria strains were determined. The lowest MIC values were obtained with B. pumilis, B. subtillis and S. epidermidis (1.87 mg/mL), followed by Staphylococcus aureus and Escherichia coli (7.50 mg/mL) and the highest were obtained with Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococcus faecalis (15.00 mg/mL). The cell proliferation and standard cytotoxicity assays of Euphorbia Condylocarpa root extract were revealed that there is no toxic against L929 normal cell line. Based on the current investigation, it is potentially suggested that methanolic Euphorbia Condylocarpa root extract can be proposed as an antibacterial agent and it can be further assessed to discover bioactive natural products involved in its activity.

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