Antimicrobial activity of methanolic root extracts of Euphorbia condylocarpa against pathogenic bacteria

Abstract

In the present study, the antibacterial activity effect of methanolic root extracts of Euphorbia Condylocarpa was evaluated against five Gram positive, three Gram negative bacterial strains. The antibacterial activity was determined by agar disk diffusion method. The most susceptible bacteria to Euphorbia Condylocarpa root extracts were Bacillus subtillis, B. pumilis and Staphylococcus epidermidis and displayed larger inhibition zones than Gram negative bacteria. Minimum inhibition concentrations (MIC) of extract against these bacteria strains were determined. The lowest MIC values were obtained with B. pumilis, B. subtillis and S. epidermidis (1.87 mg/mL), followed by Staphylococcus aureus and Escherichia coli (7.50 mg/mL) and the highest were obtained with Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococcus faecalis (15.00 mg/mL). The cell proliferation and standard cytotoxicity assays of Euphorbia Condylocarpa root extract were revealed that there is no toxic against L929 normal cell line. Based on the current investigation, it is potentially suggested that methanolic Euphorbia Condylocarpa root extract can be proposed as an antibacterial agent and it can be further assessed to discover bioactive natural products involved in its activity.

Richardia brasiliensis Collected in Southern-Benin: Phytochemical Screening, Antimicrobial Activity and Toxicity

“…In our study, the MICs are between 1.25 and 5 mg/ml for the reference strains tested, whereas for strains isolated from skin infections the mean MICs are between 0.9375±0.94 and 2.97 ±0.47 mg/ml. These values are largely lower than those of Mohammadi et al [37] who had found MIC values between 62.5 and 250 mg/ml with the methanolic extract of Euphorbia condylocarpa root on the strains studied. Oikeh et al [38] found MIC values between 12 µg/ml and 25 µg/ml on some Gram-negative bacteria using concentrated Juices from the fruits of the genus Citrus.…”

Antimicrobial activity of leaf extracts of Euphorbia paralias L. and Melilotus sulcatus Desf. against some pathogenic microorganisms

“…According to the method of Mohammadi et al, (2015), with minor modifications, 50 gm of the powder of Euphorbia paralias and Melilotus sulcatus were filled in the thimble and extracted successively with 300 ml each of sterile distilled water and methanol using a Soxhlet apparatus for 24 hours. All the extracts were evaporated using a rotary evaporator.…”

Assessing the Anticancer Effect of the Euphorbia condylocarpa Plant on AGS Gastric Cancer Cell Line

“…Also, there are different reports about the antifungal activities of some species of Euphorbial like E. tirucalli and E. hitra (11). Euphorbia condylocarpa (local name is Shoaleh Kolah) that exists in Iran (12,13) is one of the major species of Euphorbia. Further distribution of this plant is in Kurdistan province and, also, it is really common as an effective drug to treat constipation and intestinal infection (14).…”