Introduction: This study was conducted aimed to determine the relationship between a healthy lifestyle, self-esteem and subjective vitality of the elderly in Sirjan in 2020.Method: In this descriptive-analytical study, 200 elderly people aged 60 years and older were selected from comprehensive health centers in Sirjan by two-stage random sampling method. The data were collected using validated Healthy Lifestyle Questionnaire among Iranian Elderly, Rosenberg Self-Esteem Scale and validated Subjective Vitality Scale.Results: The mean and standard deviation of healthy lifestyle score was 134.42±13.78, 36.34±4.62 for self-esteem and 21.80±2.85 for subjective vitality. A direct and significant relationship was between healthy lifestyle and self-esteem (p <0.001) and between healthy lifestyle and subjective vitality (p <0.001).Conclusion: A direct and significant relationship was between healthy lifestyle, self-esteem and subjective vitality of the elderly. Therefore, the elderly should take care of their health and benefit from self-esteem and vitality by selecting a healthy lifestyle.