In this work, an oxidation‐responsive thioether‐functionalized poly(N‐isopropylacrylamide) is reported, which is synthesized via reversible‐addition fragmentation transfer (RAFT) polymerization using 6‐(methylthio)hexyl acrylate or 2‐(methylthio)ethyl acrylate as comonomers and S‐ethyl‐S′‐(a,a′‐dimethyl‐a″‐acetic acid)trithiocarbonate as RAFT agent, investigating the influence over the lower critical solution temperature (LCST) of the random thioether functionalities, prior and upon oxidation. The hydrophobic thioethers shift the LCST values of the resulting copolymers to very low temperatures, but the value could be regulated upon oxidation due to the huge increase in dipolar moment. The resulting copolymers containing hydrophilic sulfoxides show much higher LCST values, reaching a difference of up to 23 °C after oxidation. Results are supported by 1H NMR, size exclusion chromatography, and turbidimetry measurements.

The Carbon-based nanomaterials play a vital role because of they are biocompatible, economical, efficient, stable and environmental-friendly nature, which makes superior to use them in biotechnology, biomedical, electronics and electrical applications. Under the classification of carbon-based nanomaterials, carbon nanofibers (CNFs) are the predominantly used nanomaterial in many healthcare applications due to nontoxicity. CNFs are easily and uniformly dispersible in nature when compared to other carbon-based nanomaterials. In this study, the first part discusses about the acidfunctionalization of CNFs. The second part discusses the preparation and characterization of Functionalized CNF (F-CNF)-Gelatin/PVA hydrogel. And, the final part concentrates to enhance the electrical conductivity of the hydrogel. The main objective of this work is to study the effect of hydrogel formed via acid functionalized CNF as a crosslinker in the conducting nanocomposite. Additionally, analysis on functionality of the prepared hydrogel on ECG electrode application was discussed in this paper. In comparison with conventional nano-based electrodes, the current work with F-CNF based conducting nanocomposite hydrogel patch has better performance which involves usage of less harsh chemicals. It can able to efficiently monitor biosignals, such as in electromyography and electroencephalography.