IntroductionL'automédication est devenue un phénomène émergeant et menaçant de plus en plus la santé publique. La présente étude objective de déterminer la prévalence et les caractéristiques dans le campus Universitaire Kasapa de l'Université de Lubumbashi.MéthodesL'interview indirecte a servi à la collecte des données qui ont été traitées par le logiciel Graphpad version 5.RésultatsDe 515 étudiants consultés, l'automédication présente une prévalence de 99%, une partie des sujets l'ayant débutée à l'adolescence (35%). Des répondants, 78,8% reconnaissent que l'automédication peut conduire à un échec thérapeutique et que des erreurs de dose, un traitement inadapté, des effets secondaires et des erreurs diagnostiques sont plausibles. Cette pratique est acceptée pour autant qu'elle permette de prendre en charge des maladies ou symptômes présumés bénins et connus avec pour avantages, discrétion et économie de temps et d'argent. La malaria (82,4%), la fièvre (65,5%), les maux de tête (65,5%) en constituent les trois premières causes. L'amoxicilline (98,2%), le paracétamol (97,5%), l'acide ascorbique (91,6%) et la quinine (79,4%) sont les quatre premiers médicaments les plus consommés. L'association la plus utilisée est paracétamol’ vitamine(s) (88,8%) et la plus aberrante amoxycilline -Erytromycine (25,5%). Le comprimé (37%) constitue la forme la plus utilisée. La plupart des sujets (84,9%), recourent aux plantes médicinales.ConclusionDans ce milieu, il existe une forte prévalence de l'automédication largement dans un but antipalustre avec quelques abus.

A previous study inventoried 53 plants used in traditional medicine in Bagira in Eastern Democratic Republic of Congo (DRC) in the management of malaria. During malaria disease, oxidative stress is responsible for the worsening of the patient's condition. This study aims to identify phytochemical groups and to evaluate antioxidant activity of 53 plants used in traditional medicine in Bagira to treat malaria. The phytochemical screening was carried out by conventional reactions in solution and antioxidant activity used in vitro method with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). Chemical screening has identified secondary metabolites with both antimalarial and antioxidant potential such as coumarins, steroids, saponins, tannins and terpenoids in more than 70% of plants. Antioxidant screening revealed for the first-time antioxidant activity of 18 plants, among which Dalbergia katangensis, Dialium angolense and Solanecio cydoniifolius with IC50 ≤ 1.6 µg / mL having the highest activities. This study shows that among plants used as antimalarial in Bagira several possess antioxidant power and contain many of groups presumed to be both antioxidant and antimalarial. This suggests that further studies continue to isolate compounds responsible for the proven activity.

Pharmaceutical counterfeiting is a health scourge responsible for several cases of morbidity and mortality. Counterfeit medicines cause therapeutic failure, emergence of resistance in the treatment of infections. This study was conducted in order to identify counterfeit and authentic medicines in circulation in Lubumbashi. The study included artemether and artesunate for oral administration. A careful visual inspection of medicine, investigation of authenticity of pharmaceutical products from manufacturers and pharmaceutical regulatory authorities and determination of content were used as study parameters. 52 samples: 37 artemether and 15 of artésunate were collected. 7 samples (13%) have proven to be counterfeit. Artemether was the most counterfeit (71%) and 29% for artesunate. 6 (12%) samples were substandard according to the international pharmacopoeia in terms of content of active ingredient. Sixty-seven percent of non-compliance concerned counterfeit medicines. The proportion of non-compliance is highest among counterfeit medicines (71.43% vs 2.22%; p = 0.000004). It is obvious that strengthening the capacity of the drug regulatory authority of the DRC reduces the influx of counterfeit drug and substandard.

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