The aim of this study was to observe the features of chronic gastritis in children with celiac disease (СD). Materials and methods. 176 children with chronic gastritis (CG) aged from 3 to 16 years were examined. Group I consisted 58 child ren with CG and newly diagnosed CD not adherent to the gluten-free diet (GFD), group II consisted 49 children with CG and CD, adherent to the GFD. In the group III of comparisons were 69 children with CG and excluded CD. The exa mination included serological, morphological methods to confirm or exclude CD. The histological examination of the biopsy specimens of the gastric mucosa, the determination of antiparietal antibodies by the method of iIFR and ELISA (antibodies to Castle’s intrinsic factor and Anti-H+/K+ ATPase antibodies) were carried out. Results. Helicobacter pylori infection was diagnosed in vast majority of patients in all groups. Autoantibodies to the gastric mucosa were found in every tenth patient in groups I and III, and did not occur in group II. In group II statistically significant the etiology of gastritis remained not determined. Endoscopically the gastric mucosa in groups I and II often remained intact. Accor ding to the morphological study in groups I and II, the pathological process was more often localized in the body of the stomach, and in group III in the antrum. Autoimmune gastritis is presented in groups without a statistically significant difference. Conclusion. Chronic gastritis is a frequent co-morbid pathology in СD, and it is also not uncommon in these patients. Data of endoscopy in children, regardless of diet, does not reflect the complete picture of CG. All children with CD, regardless of compliance with GFD, are recommended to take biopsy specimens of the gastric mucosa for histological examination in order to exclude CG, and in case of detecting atrophic changes in the gastric mucosa to define the antiparietal antibodies.

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We studied biopsies of gastric mucosa and the gastric antrum bodies obtained from 60 children with chronic gastritis and chronic gastritis in combination with chronic glomerulonephritis. Clinical data of patients (age, gender, duration of the underlying disease, conducted therapy, the results of laboratory and instrumental studies) were studied. It conducts research using histological and immunohistochemical methods. A morphological study of the sections found gastrobiopsies characteristic manifestations of chronic gastritis c signs of chlamydial lesions. The immunohistochemical method determined Chlamidia trachomatis antigens in the antrum and corpus. The positive expression in the epithelial cells of glands and endothelial microvascular gastric mucosa with concomitant lesions of the stomach and kidneys. The possibility of the development of chronic gastritis chlamydial infection in chronic glomerulonephritis. Based on the obtained results was made comprehensive assessment of the gastric mucosa based on morphological, immunohistochemical and clinical data. The features of stromal-vascular responses in the development of chronic gastritis occurring in isolation and combined with chronic glomerulonephritis. The effect of steroid therapy, as a cause of decrease in protective mechanisms of gastric mucosa in children. The data supporting the need for immunohistochemical studies for the etiologic diagnosis of chronic gastritis and the subsequent selection of appropriate therapy.

Achievements in modern medicine, allowed since 2012, significantly reduce perinatal mortality in the Russian Federation. Despite the impressive rate of decline in perinatal mortality, there are still quite a few deaths that could be prevented. Causes and mechanisms of death in the perinatal period, starting from the 22nd week of intrauterine fetal development, on the 7th day after birth, are significantly different from the tanatogenesis in a patient living more than 7 days. Our work presents perinatal mortality rates in the Russian Federation for the period from 2010 to 2016 and formulates recommendations for the consistent implementation of all stages of an autopsy of the deceased in the perinatal period in full. Issues of approaches to pathoanatomical research, principles of diagnosis formulation and correct registration of medical documentation in stillbirth and in cases of death in the early neonatal period were discussed. The main criteria that allow differential diagnostics between antenatal intrapartum fetal death and the death of a child in the early neonatal period are considered. In addition, we have developed a classification of pathoanatomical diagnosis, taking into account the characteristics of the perinatal period and the interaction in the “mother-placenta-fetus” system. The authors note that in the case of a fatal outcome in the perinatal period, the final pathoanatomical diagnosis, in addition to the generally accepted headings, should take into account the mother's condition (pathology of pregnancy, childbirth), as well as the pathology of the afterbirth.