Deep Learning analysis of CXR photographs is a promising tool. Further efforts are needed to build larger, high-quality data sets to achieve better diagnostic performance.

The serotonin transporter (5-HTT) plays a key role in regulating serotonergic transmission via removal of serotonin (5-hydroxytryptamine, 5-HT) from synaptic clefts. Alterations in 5-HTT expression and 5-HT transmission have been shown to cause changes to adult behavior including fear. The objective of the present study was to investigate the 5-HTT role in fear in birds at the very early stages of post-hatching life. Using an avoidance test with an elevated balance beam, which was based on depth perception and the respective fear of heights, we assessed fear-related avoidance behaviors of newly hatched chicks of the three functional 5-HTT genotypes W/W, W/D and D/D. Newly hatched chicks of the genotype D/D, which was linked to high 5-HTT expression, showed less intensive avoidance responses as measured by decreased latency to jump than W/W and W/D chicks. Further, significantly fewer D/D hens than W/W hens showed fear-like behavior that resembled a freezing response. Furthermore, in an arousal test the arousal reaction of the chicks in response to an acute short-term visual social deprivation in the home compartment was assessed 5 weeks after hatching, which also revealed that D/D chicks exhibited decreased arousal reaction, compared to W/W chicks. Thus, the results indicate that fear responses differ in D/D chicks in the early post-hatching periods, possibly due to the different expression of 5-HTT respectively 5-HT levels in this strain.

To evaluate the feasibility of accelerated simultaneous multislice diffusion weighted sequences (SMS-DWI) for lymph node detection in the abdominopelvic region. Sequences were evaluated regarding the number and depiction of lymph nodes detected with SMS-DWI compared with conventional diffusion weighted sequences, the most suitable SMS- acceleration factor, signal-to-noise ratio (SNR), and the overall acquisition time (TA).Eight healthy volunteers (4 men, 4 women; age range 21–39 years; median age 25 years) were examined in the pelvic region at 3T using a conventional DWI sequence and a SMS DWI sequence with different acceleration factors (AF: 2–3). Moreover, a SMS DWI sequence with AF 3 and higher slice resolution was applied. For morphological correlation of the lymph nodes and as a reference standard, an isotropic 3-dimensional T2-weighted fast-spin-echo sequence with high sampling efficiency (SPACE) was acquired. Two radiologists reviewed each DWI sequence and assessed the number of lymph nodes and the overall image quality. For each DWI sequence, SNR, SNR efficiency per time, contrast to noise (CNR), and ADC values were calculated. Values were statistically compared using a Wilcoxon test (P < .05).Overall, scan time of SMS-DWI with AF2 (AF3) decreased by 46.9% (57.2%) with respect to the conventional DWI. Compared with the SPACE sequence, the detection rate was 89.6% for conventional DWI, 69.4% for SMS-DWI with AF2, and 59.9% for SMS-DWI with AF3. The highly resolved SMS-DWI with AF3 leads to a scan time reduction of 46.9% and detection rate of 83.0%. SNR and CNR were lower in the accelerated sequences (up to 51.0%, P < .001) as compared with the conventional DWI. SNR efficiency decreased to 19.3% for AF2 and to 31.3% for AF3. In the highly resolved dataset, an SNR efficiency reduction of 51.2% was found.This study showed that lymph node detection in the abdominopelvic region with accelerated SMS-DWI sequences is feasible whereby an AF of 2 represents the best compromise between image quality, SNR, CNR, TA, and detection rate.

Simultaneous multislice acceleration provides considerable scan time reduction for upper abdomen DWI with equivalent quality of IVIM analysis compared with the standard nonaccelerated technique. Systematic discrepancies of the true Dt, D*, and Fp for SMS acquisitions need to be considered when comparing to standard DWI sequences.

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