Background Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0•9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0•9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124.

No abstract

Few European adults were practicing 5 healthy behaviors. This should be a message for governments and be considered in the establishment of preventive public policies in the areas of health and health education.

Título: ¿Qué distingue a los equipos de los agregados sociales? Un instrumento para evaluar el desarrollo del grupo. Resumen: Esta investigación utiliza el constructo de desarrollo del grupo (GD) para distinguir grupos de trabajo y equipos altamente desarrollados de los meros agregados sociales. Los objetivos fueron desarrollar una escala capaz de medir este proceso emergente básico y estudiar la fiabilidad y validez de constructo de la escala (de contenido, factorial, convergente y orientada al criterio). Los datos relativos al GD y otros procesos relacionados (entitatividad e identificación del grupo) y resultados del equipo (desempeño y efectividad del grupo) se obtuvieron de cuatro estudios sucesivos (4099 participantes pertenecientes a 559 grupos de trabajo de 12 organizaciones). Todos los estudios se llevaron a cabo utilizando un diseño transversal y correlacional. Los resultados revelaron una solución unidimensional de la escala propuesta, que demostró validez y fiabilidad adecuadas. La escala no sólo es práctica (rápida y fácil de aplicar), sino que también es útil para los gestores y líderes de grupos ya que les proporciona una herramienta para determinar el grado en que sus grupos funcionan en realidad como equipos altamente desarrollados. Palabras clave: grupos de trabajo; equipos; desarrollo del grupo; cuestionario de autoinforme; validez de constructo.Abstract: This research uses the construct of group development (GD) to distinguish highly developed workgroups and teams from mere social aggregates. The aims were to develop a scale capable of measuring this basic emergent process and to study the scale's reliability and construct validity (content, factorial, convergent and criteria). Data concerning the GD, other related processes (entitativity and group identification) and team outputs (group performance and team effectiveness) were gathered from four successive studies (4099 participants belonging to 521 workgroups in 13 organizations). All the studies were carried out using a cross-sectional and correlational design. The results revealed an one-dimensional solution for the proposed measurement scale, which showed adequate reliability and validity. The scale is not only practical (quick and easy to apply) but also useful for group managers and leaders, since it provides them with a tool for determining the extent to which their groups are actually functioning as highly developed groups.

El objetivo del presente estudio fue analizar la asociación del nivel de condición física con variables de rendimiento cognitivo como memoria, cálculo matemático, velocidad de razonamiento lingüístico y creatividad. La muestra estaba formada por 163 adolescentes (78 chicas y 85 chicos) de 13,9 ±1,4 años. La memoria se evaluó mediante una adaptación propia basada en la prueba RIAS. Para el cálculo matemático y el razonamiento lingüístico se usaron tests ad hoc y para la creatividad el test CREA. Los análisis mostraron que la resistencia cardiorrespiratoria de los jóvenes se asocia a mejores niveles de memoria (p = ,027), cálculo matemático (p = ,035), razonamiento lingüístico (p = ,014) y creatividad (p = ,005), independientemente de la edad, sexo e índice de masa corporal de los jóvenes. Sin embargo, mejores niveles de velocidad-agilidad, fuerza y flexibilidad no se relacionaron con mejoras en ninguna de las variables dependientes analizadas (todos p > ,05). Se concluye que la resistencia cardiorrespiratoria es el componente de la condición física que en mayor medida se relaciona con altas capacidades cognitivas de los jóvenes. Se sugiere, que desde la Educación Física se implementen programas específicos para incrementar el nivel de capacidad cardiorrespiratoria, con prácticas sistemáticas especialmente durante el periodo extraescolar. Abstract: The aim of the present study was to analyze the association of the level of physical fitness with variables of cognitive performance such as memory, mathematical calculation, speed of linguistic reasoning, and creativity. The sample consisted of 163 adolescents (78 girls and 85 boys) aged 13.9 ± 1.4 years old. Memory was evaluated through an own adaptation based on the RIAS test. Ad hoc tests were used for mathematical calculation and linguistic reasoning, and the CREA test for creativity. The analyses showed that youth’s cardiorespiratory fitness is associated with better levels of memory (p = ,027), mathematical calculation (p = ,035), linguistic reasoning (p = ,014), and creativity (p =,005) regardless of age, sex, and body mass index. However, better levels of speed-agility, strength, and flexibility were not related with improvements in any of the dependent variables analyzed (all p > ,05). Cardiorespiratory fitness is the physical fitness component with the highest relation with cognitive abilities in youngsters. We suggest the implementation of specific programs aimed at increasing cardiorespiratory fitness levels through Physical Education, especially employing systematic physical activity practices during the extracurricular period.