Taken together, the alterations described seem to contribute to constituting a state of higher propensity for the development of atherosclerotic cardiovascular disease, which adds to the presence of specific cardiomyopathy.
In patients with chronic paracoccidioidomycosis (n ؍ 10), levels of tumor necrosis factor alpha, interleukin-10, and interleukin-2 in serum, measured by enzyme-linked immunosorbent assay (in picograms per milliliter, as mean ؎ standard error of the mean), were higher than in normal controls (n ؍ 8): 186 ؎ 40 versus 40 ؎ 7 (P < 0.05), 203 ؎ 95 versus 20 ؎ 8 (P ؍ 0.001), and 96.3 ؎ 78.57 versus 1.19 ؎ 1.19 (P ؍ 0.045), respectively. Gamma interferon and interleukin-4 levels were similar in patients and controls.
The abnormal distribution of leukocytes, high TH1 cytokines and a low TGF-beta1 associated with reproductive failure, respond to ovarian stimulation, achieving total or partial normalization.
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