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Silver Nanoparticles (AgNPs) are gaining importance in the place of traditionally used silver nitrate for wound dressings with antimicrobial properties. AgNPs were synthesised in situ in the chitosan-polyethylene oxide (PEO)-silk fibroin (SF) film. The characterization of chitosan-PEO-SF film with AgNPs using FTIR, SEM-EDAX techniques showed the presence of AgNPs and its distribution in the film. Tensile strength and % elongation of chitosan-PEO-SF film with AgNPs showed good mechanical property. Release kinetics of silver nanoparticles from chitosan blend film was studied using various mathematical models such as zero-order kinetics, first order kinetics, Higuchi model and Power law model. From all the above models, based on coefficient of correlation (R 2) value (0.92), it was confirmed that the release of AgNPs from chitosan-PEO-SF film followed power law model. The release of silver nanoparticles from chitosan film depends on dissolution of the AgNPs. Antimicrobial efficacy of the chitosan-PEO-SF film with AgNPs was comparatively studied against two wound colonizing pathogens such as B.subtilis and P.aerugenosa and it showed significant reduction in cell density. Therefore, the film developed in present study can be used to prepare wound dressings in the clinical set up.

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