Cancer is the one of the highest killers in the world. In Indonesia, the prevalence of this disease is increasing from year to year. To reduce the number of cancer patients, the Ministry of Health has a variety of efforts, such as education to the public through Public Service Announcement (PSA) on television. PSA is needed primarily to mobilize the community to change behavior to a more positive direction as desired by the communicator. It takes proper persuasive communication so that the PSA can perform its function to influence people to change their behavior in a positive direction. This persuasive effort becomes interesting to be studied considering persuasive communication is related to various aspects, such as attitude, behavior and knowledge of target audience. In the context of cancer education, persuasive communication is needed to convince people to be more concerned about cancer by implementing a healthy lifestyle so that cancer can be prevented. This study aims to find how persuasive communication in cancer education PSA could support behavior change in society. The research method used is case study using qualitative descriptive, trough data collection procedure of FGD (Focus Group Discussion). The research was conducted in Cirendeu, Ciputat. Data survey was obtained from the students of the University of Muhammadiyah Jakarta who became informers. The data is analyzed qualitatively which is then interpreted and presented in the form of a description or narrative followed by conducted theoretical interpretation to give meaning to the result of the research that has been done. Result of this study indicates that behavior of the target audience towards the PSA is quite positive. Some of informants like the storyline and animation aproach, but the weakness is the information in the PSAis less detailed. Information in persuasive communication of PSA seeks to change the pattern of community to be healthier where early examination or detection is needed as a form of prevention. Through PSA, public awareness of cancer can be increased to persuade people to be willing to prevent cancer. ABSTRAKKanker adalah salah satu pembunuh tertinggi di dunia. Di Indonesia, prevalensi penyakit ini meningkat dari tahun ke tahun. Untuk mengurangi jumlah penderita kanker, Kementerian Kesehatan memiliki berbagai upaya, seperti edukasi ke masyarakat melalui Public Service Ads (ILM) di televisi. ILM sangat dibutuhkan terutama untuk memobilisasi masyarakat agar mengubah perilaku ke arah yang lebih positif seperti yang diinginkan oleh komunikator. Dibutuhkan komunikasi persuasif yang tepat sehingga ILM dapat menjalankan fungsinya untuk mempengaruhi orang untuk mengubah perilaku mereka ke arah yang positif. Upaya persuasif

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