Though Rice is cultivated in huge quantities, various disease causing agents will reduce the yield leading to not only losing the economy but also a food crisis. Production of rice is constrained by fungal, bacterial and viral diseases. In the current review, we focused on various pathological symptoms in Oryza species that cause high yield losses. In this context, plant breeders are attempting progressive research activity to achieve more yield and disease-resistant varieties that balance the world’s rice demand and increase the farmers' income. Rice was recognized as a genetic model for research in genetics and molecular biology, for understanding growth, development, tolerance to stress and disease resistance because of its small genome. The present review focuses on the various causative agents of diminishing rice yield along with the strategies to eradicate the pathogen and thereby increasing the yield. Recent research advances at genetic level have paved a way for novel approach to understand the significance between the pheno-genotypic variations with the crop yield of rice. Further, the review also includes the advanced methodologies at molecular level so as to save the rice cultivators from economic crisis. Disease resistant genes are identified and screened using molecular markers like SSR (simple sequence repeats), RAPD (Randomly Amplified Polymorphic DNA), and RFLP (restriction fragment length polymorphisms) analysis. There exist few reports in the literature about rice cultivation, but to the best of our knowledge in a single review both cause and remedy were not discussed in detail. In this context, our review provides an insight into the aspects attributing the crop loss followed by suggesting the suitable alternative method for enhancing crop yield.

The concept of metabolic regulations deals with the varied and innumerable metabolic pathways that are present in the human body. A combination of such metabolic reactions paves the way for the proper functioning of different physiological and biological functions. Dealing with the adversities of a disease, engineering of novel metabolic pathways showcase the potential of metabolic engineering and its applications in the therapeutic treatment of diseases. A proper and deeper understanding of the metabolic functions in the human body can be known from gut-microflora and simulated yeast models. At molecular level, the metabolic regulation works mainly by modulation of the activities of the enzyme. This gives a brief understanding about the interactions between the molecular set of metabolomes and its complexity. The idea of model simulation can help us to draw some possible hypotheses regarding how different the components of a certain pathway are connected. Introduction of engineered microorganisms into the gut might bring about the required variation in the microbiota, thereby inducing them to express certain biomarkers specific to certain microbial groups forming a basis for disease diagnosis and pathogenesis. Since the metabolic homeostasis and observable phenotype are linked to each other, metabolism can be used as a diagnostic of the phenotype. The present review, therefore, focuses on the importance of both the gut-microbiota and yeast model in improving our understanding about the metabolic regulations involved in human health and disease.

Though Rice is cultivated in huge quantities, various disease causing agents will reduce the yield leading to not only losing the economy but also a food crisis. Production of rice is constrained by fungal, bacterial and viral diseases. In the current review, we focused on various pathological symptoms in Oryza species that cause high yield losses. In this context, plant breeders are attempting progressive research activity to achieve more yield and disease-resistant varieties that balance the world’s rice demand and increase the farmers' income. Rice was recognized as a genetic model for research in genetics and molecular biology, for understanding growth, development, tolerance to stress and disease resistance because of its small genome. The present review focuses on the various causative agents of diminishing rice yield along with the strategies to eradicate the pathogen and thereby increasing the yield. Recent research advances at genetic level have paved a way for novel approach to understand the significance between the pheno-genotypic variations with the crop yield of rice. Further, the review also includes the advanced methodologies at molecular level so as to save the rice cultivators from economic crisis. Disease resistant genes are identified and screened using molecular markers like SSR (simple sequence repeats), RAPD (Randomly Amplified Polymorphic DNA), and RFLP (restriction fragment length polymorphisms) analysis. There exist few reports in the literature about rice cultivation, but to the best of our knowledge in a single review both cause and remedy were not discussed in detail. In this context, our review provides an insight into the aspects attributing the crop loss followed by suggesting the suitable alternative method for enhancing crop yield.

Though Rice is cultivated in huge quantities, various disease causing agents will reduce the yield leading to not only losing the economy but also a food crisis. Production of rice is constrained by fungal, bacterial and viral diseases. In the current review, we focused on various pathological symptoms in Oryza species that cause high yield losses. In this context, plant breeders are attempting progressive research activity to achieve more yield and disease-resistant varieties that balance the world’s rice demand and increase the farmers' income. Rice was recognized as a genetic model for research in genetics and molecular biology, for understanding growth, development, tolerance to stress and disease resistance because of its small genome. The present review focuses on the various causative agents of diminishing rice yield along with the strategies to eradicate the pathogen and thereby increasing the yield. Recent research advances at genetic level have paved a way for novel approach to understand the significance between the pheno-genotypic variations with the crop yield of rice. Further, the review also includes the advanced methodologies at molecular level so as to save the rice cultivators from economic crisis. Disease resistant genes are identified and screened using molecular markers like SSR (simple sequence repeats), RAPD (Randomly Amplified Polymorphic DNA), and RFLP (restriction fragment length polymorphisms) analysis. There exist few reports in the literature about rice cultivation, but to the best of our knowledge in a single review both cause and remedy were not discussed in detail. In this context, our review provides an insight into the aspects attributing the crop loss followed by suggesting the suitable alternative method for enhancing crop yield.