The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC—drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.
O estudo foi desenvolvido com três objetivos integrados: (i) adquirir referencial teórico sobre a temática do óleo residual de cozinha e os impactos causados pelo descarte inadequado; (ii) aplicar o método etnográfico para obtenção de dados sobre a cultura da fabricação de sabão artesanal no Munícipio de Paramirim/BA; (iii) realizar análise laboratorial da qualidade do sabão produzido. Para apreensão dos dados foi realizado: (i) estudo bibliográfico; (ii) método etnográfico (Martyn Hammersley e Paul Atkinson, 2007); (iii) análise sensorial, testes de densidade, teor de umidade, propriedade de consistência e potencial hidrogeniônico (pH). O método etnográfico foi eficiente para apreensão dos dados no contexto social estudado. A análise laboratorial constatou que uma das amostras possui pH básico muito elevado, podendo causar riscos à saúde dos fabricantes e usuários do sabão. Os dados empíricos fundamentam uma proposta de educação ambiental com as mulheres na Bahia.
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