Organophosphates (OPs) pesticides are among the most toxic synthetic chemicals purposefully added in the environment. The common use of OP insecticides in public health and agriculture results in an environmental pollution and a number of acute and chronic poisoning events. Present study was aimed to evaluate the potential of monocrotophos and quinalphos to effect the redox status and glutathione (GSH) homeostasis in rat tissues and find out whether antioxidant vitamins have some protection on the pesticide-induced alterations. The results showed that these pesticides alone or in combination, caused decrease in the levels of GSH and the corresponding increase in the levels of GSSG, decreasing the GSH/GSSG ratio. The results also showed that NADPH/NADP(+) and NADH/NAD(+) ratios were decreased in the liver and brain of rats on exposure with mococrotophos, quinalphos, and their mixture. These pesticides, alone or in combination, caused alterations in the activities of GSH reductase and glucose-6-phosphate dehydrogenase in the rat tissues. However, the expression of the GSH recycling enzymes did not show significant alterations as compared to control. From the results, it can be concluded that these pesticides generate oxidative stress but their effects were not synergistic when given together and prior feeding of antioxidant vitamins tend to reduce the toxicities of these pesticides.

Diabetes is a life-threatening metabolic disorder. This study was undertaken to evaluate the antihyperglycemic and antioxidative potential of seed powder of Trigonella foenum-graecum L in alloxan (55 mg/kg) induced diabetic rats. The results obtained showed that extensive oxidative stress is generated in tissues of diabetic rats as evidenced by increased production of hydrogen peroxide, increased accumulation of malondialdehyde (MDA) and 4-hydroxynonanal (4HNE) and decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in tissues of diabetic rats. It was observed that the transcription of genes of SOD, GPx, and CAT was also significantly decreased when compared with control. Treatment of Trigonella for 15 days to diabetic rats showed hypoglycemic effect and improved the altered levels of H2O2, MDA, and 4HNE, the activities of SOD, GPx, and CAT as well as transcription of these genes in the liver and the brain of diabetic rats.

Obesity and associated non-communicable illnesses including coronary heart disease, type 2 diabetes, and stroke have steadily increased in prevalence over the last decade. Previous studies identified the involvement of individual, family, and community support intervention strategies used to prevent and manage obesity. Additionally, education on nutrition from the early stages of development is crucial for obesity prevention and control. Therefore, new preventative methods are needed to further engage and educate individuals and communities about health-conscious diets. Microgreen cultivation utilizes a reduced cost, low-footprint, recyclable, weather-independent, and transportable method to provide less nutrition-privileged communities with exposure to healthy foods within one week. A pilot microgreens outreach event, held at a medical school, tested for feasibility, and assessed for potential complications from utilizing microgreen cultivation as a teaching tool. Ninety-four first- and second-year medical students elected to participate in the pilot event and received a microgreen growing kit and a pre-and post-planting survey. Upon survey completion, nutrition attitudes and awareness levels were tracked. Analysis of survey results reveals that participants met this low-cost and easy teaching tool with enthusiasm, high levels of engagement, and minimal complications.

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