The occurrence of Coronary heart disease (CHD) is hard to predict yet, but the assessment of CHD risk for the next ten years is possible. The prediction of coronary heart disease can be modelled using multi-layer perceptron neural network (MLP-ANN). Prediction model with MLP-ANN has either positive or negative CHD output, which is a binary classification. A prediction model with binary classification requires determination of threshold value before the classification process which increases the uncertainty in the classification process. Another weakness of the MLP-ANN model is the presence of overfitting. This study proposes a prediction model for coronary heart disease using the duo output artificial neural network ensemble (DOANNE) method to overcome the problems of overfitting and uncertainty of classification in MLP-ANN. This research method was divided into several stages, namely data acquisition, pre-processing, modelling into DOANNE, neural network ensemble training with Levenberg-Marquard (LM) algorithm, system performance testing, and evaluation. The results of the study showed that the use of DOANNE-LM method was able to provide a significant improvement from the MLP-ANN method, indicated by the results of statistical tests with pvalue <0.05.

The occurrence of Coronary heart disease (CHD) is hard to predict yet, but the assessment of CHD risk for the next ten years is possible. The prediction of coronary heart disease can be modelled using multi-layer perceptron neural network (MLP-ANN). Prediction model with MLP-ANN has either positive or negative CHD output, which is a binary classification. A prediction model with binary classification requires determination of threshold value before the classification process which increases the uncertainty in the classification process. Another weakness of the MLP-ANN model is the presence of overfitting. This study proposes a prediction model for coronary heart disease using the duo output artificial neural network ensemble (DOANNE) method to overcome the problems of overfitting and uncertainty of classification in MLP-ANN. This research method was divided into several stages, namely data acquisition, pre-processing, modelling into DOANNE, neural network ensemble training with Levenberg-Marquard (LM) algorithm, system performance testing, and evaluation. The results of the study showed that the use of DOANNE-LM method was able to provide a significant improvement from the MLP-ANN method, indicated by the results of statistical tests with pvalue <0.05.