Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with heterogeneous clinical presentations and potential lethal outcomes. The diagnosis is based on clinical suspicion, biochemical testing, imaging and histopathological confirmation. Increasingly widespread use of imaging studies and surveillance of patients at risk of PPGL due to a hereditary background or a previous tumor is leading to the diagnosis of these tumors at an early stage. This has resulted in an increasing use of the term “silent” PPGL. This term and other variants are now commonly found in the literature without any clear or unified definition. Among the various terms, “clinically silent” is often used to describe the lack of signs and symptoms associated with catecholamine excess. Confusion arises when these and other terms are used to define the tumors according to their ability to synthesize and/or release catecholamines in relation to biochemical test results. In such cases the term “silent” and other variants are often inappropriately and misleadingly used. In the present analysis we provide an overview of the literature and propose standardized terminology in an attempt at harmonization to facilitate scientific communication.
Technological opportunities have a transformative impact on labour markets. In this article, we aim to study the ways in which digital technologies contribute to the development of the digital model of the labour market and digital platforms. We aim to highlight digital opportunities to support efforts to ensure the development of strategies, policies and labour market transformations. We intend to build the digital model of the labour market within the model of the systemic digital economy, in close connection with other digitalization models (business, financial markets, public finance, commerce, industry, agriculture, transport). An important part of the study focuses on the opportunities for sustainable financing of the digitized labour market, as financial services interact closely with labour market institutions, which reflect on labour outcomes. We propose that the digital model of the labour market in close correlation with the digital business model will developed with investments from employers in the training of employees in digitization, new modern professional knowledge, which will allow an integration of companies in global markets. The financial-monetary dimension of companies in the context of globalization also requires radical transformations to ensure companies' access to the international financial markets.
Starting from the observation that Sintering by Infiltration of Loose Mixture of Powders confers large possibilities for both complex shaped and of large dimensions Particulate Reinforced Metal Matrix Composite components elaboration, its mechanism comparative with those of the classical melt infiltration was investigated. Appropriate measures in order to prevent an excessive hydrostatic flow of the melt and, consequently, reinforcement particle dispersion, as well as to promote wetting in both infiltration and liquid phase sintering stages of the process were established as necessary. Some experimental results in the method application to the fusion tungsten carbide and diamond reinforced metal matrix composite elaboration are, also, presented.
Abstract:In this paper, the authors present the importance of online promotion in marketing. The article includes a theoretical part in which the main types of electronic business are presented, and also practical ways through which we can ensure online presence. The article also includes a marketing qualitative research (focus group). The research conducted must answer the question: What is the perception and the attitude of Internet users towards online buying environment. The purpose of the research is knowing the perception and users' attitude toward shopping online. Study participants have a high opinion of online stores. They identify the benefits of orders via the Internet: wide range of products, access to products not available in traditional stores, time saving, convenience, etc. But still their first option for purchasing products is traditional stores and this because of the risks associated with ecommerce website such as: the possibility of not receiving the order, the products do not comply, the products are damaged. Due to a continuous growth rate of Internet users and also due to the increasing value of transactions made online, e-commerce is present in all market fields. Promotional policy in an online business that offers services, is the key element of the marketing mix, being the decisive factor in maintaining a long-term customer relationship. It is essential that the messages that are transmitted through the promotional campaign to be concise, plausible, attractive and to be understood by all stakeholders. The campaigns must be understood by the targeted customers in order to influence the customer behavior and make a decisional difference among clients
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