Stereoselective Synthesis of (22R)-and (22S)-22-Methyl-1a,25-Dihydroxyvitamin D 3 S t e r e o s e l e c t i v e S y n t h e s i s o f ( 2 2 R ) -a n d ( 2 2 S ) -2 2 -M e t h y l -1 a,25-Dihydroxyvi t a m i n Abstract: An efficient, straightforward method for construction of the side chain of (22R)-and (22S)-22-alkyl-1a,25-dihydroxyvitamin D 3 is described. The title compounds were synthesized by Lythgoe's procedure.
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