Rheumatoid arthritis is a chronic systemic inflammatory disease whichinvolve multiple joints  of the body.The clinical symptoms of the Rheumatoid Arthritisresemble with Amavata described in Ayurvedic literature. In thisdisease, the vitiated Vatadosha and Ama spread all along the body and  localisein kaphasthana likejoints and producing symptoms like pain, stiffness, swelling, tendernessetc.Treatment principle recommended are to correct the status of the digestive fireof the bodyand balance of Vata in the body. In this case, a male patient of 28 years old presented with the symptoms of inabilityto walk and stand without support associated with pain, swelling and  stiffnessover multiple jointsalong with deformity of hands. Pain was assessed by Visual analogue score(VAS).The patient was admitted in IPD of the hospital andtreatedwith Ayurvedic  medicines and Panchakarma therapy for 28 days. Remarkable improvement was seen in pain, swelling and stiffness after the treatment.

Recent global health concern motivated the exploration of natural medicinal plant resources as an alternative target for treating COVID-19 infection and associated inflammation. In the current study, a phytochemical, 6-shogaol [1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one; 6-SHO] was investigated as a potential anti-inflammatory and anti-COVID-19 agent. In virus release assay, 6-SHO efficiently (94.5%) inhibited SARS-CoV2 replication. When tested in the inflammasome activation model, 6-SHO displayed mechanistic action by regulating the expression of the inflammasome pathway molecules. In comparison to the existing drugs, remdesivir and hydroxy-chloroquine, 6-SHO was not only found to be as effective as the standard anti-viral drugs but also much superior and safe in terms of predicted physicochemical properties and clinical toxicity. Comparative molecular dynamics simulation demonstrated a stable interaction of 6-SHO with NLRP3 (the key inflammasome regulator) in the explicit water environment. Overall, this study provides important cues for further development of 6-SHO as potential anti-inflammatory and anti-viral therapeutic agents.

Introduction: Prakriti stands for nature of the body in terms of Dosha and is decided at the time of conception according to the predominance of Dosha. According to Ayurvedic Acharyas, Prakriti of an individual cannot change during his whole life, same as blood group of an individual does not change during his life. In the present study, a relationship between Deha Prakriti and Blood Group was established. Aim and Objective: The aim of the study is to find an association between Deha Prakriti and Blood group in healthy individual. Material and Methods: For this study to be carried out, a total of 150 healthy individual (50 of each dominant prakriti) were selected. Assessment of Prakriti was done using K. Patwardhan and R. Sharma, “Prakriti: a self-assessment questionnaire” and Blood group sample was taken and investigations were carried out in pathology lab, Ch. Brahm Prakash Ayurved Charak Sansthan, Khera Dabar, Najafgarh, New Delhi and A one-way repeated measures ANOVA also known as a within-subjects ANOVA was applied to test the association between Deha prakriti and Blood group in healthy individual. Results The prevalence of different blood group as found in our study is in the order of B+, O+, A+, AB+, A-, AB-, B- and O- respectively. On analyzing the blood group with respect to Prakriti types, association was noticed between blood group type B with all single Doshaj Prakriti (Vataj, Pittaj and Kaphaj). This study shows that blood groups cannot be thus used as features to classify dominant Prakriti as no statistically significant association was found between them (p > 0.05). Keywords: Blood group, Prakriti, Vata, Pitta, Kapha.