Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations in people without hospitalization. We conducted a cross-sectional study of 87 non-hospitalized recovered individuals 54 days after the laboratory confirmation of COVID-19. We performed structured interviews, neurological examination, 3T-MRI scans with diffusion tensor images (DTI) and functional resting-state images (fMRI). Also, we investigated fatigue, anxiety, depression, somnolence, language, memory, and cognitive flexibility, using validated instruments. Individuals self-reported a high frequency of headache (40%) and memory difficulties (33%). The quantitative analyses confirmed symptoms of fatigue (68%), excessive somnolence (35%), anxiety (29%), impaired cognitive flexibility (40%) and language impairment (33%). There were widespread cerebral white matter alterations (mainly characterized by increased fractional anisotropy), which correlated with abnormal attention and cognitive flexibility. The resting-state fMRI networks analysis showed severely disrupted brain hyperconnectivity and loss of resting-state networks specificity.

Aim:The objectives of this study were to assess the influence of four different kinetic cavity preparation devices on cavity preparation taking into account tip angulation, internal tip diameter, and distance to the dental substrate. The dental topography itself was also evaluated after the use of these devices. Methods and Materials:Quantitative parameters using pertinent statistical tests as well as qualitative parameters were used to assess the topography in terms of the dispersion halo effect (DHE), size, and depth of the preparation. Results:The DHE did not present differences among the groups. In relation to the preparation size, the internal diameter influenced 120º point angles, whereas distance influenced the 90º ones. Considering the preparation depth, the 90° point angle yielded the deepest. In the qualitative analysis, both angles provided cavity preparations with rounded cavosurface angles. The 120º point angles yielded inclined, shallow V-shaped preparations, whereas the 90º angles presented U-shaped preparations reaching the dentin. The enamel had an irregular aspect and exposed prisms; dentin had a loose smear layer with aluminum oxide residues. Conclusion:The kind of device may influence the kinetic cavity design. Abstract © Seer PublishingClinical Significance: It is the clinician that knows how to select the appropriate devices to adopt in order to achieve the desired cut, depth, and shape of cavity preparations.

Introduction: McCune Albright syndrome (MAS) is a rare disorder classically defined by the triad polyostotic fibrous dysplasia (FD), café-aulait pigmentation of the skin and precocious puberty (PP). Other endocrinopathies can be associated with MAS and nonendocrine tissues such as breast may be involved. Case report: A 56-year-old woman was referred to our institution 20 years ago to treat a fast-growing infiltrative and ulcerative breast lesion, suspected as malignant. It was prompt operated and the 7 cm-tumor was classified as a bening "breast tubular adenoma". From the anamnesis it was evident café-au-lait spots (present soon after birth) and multiple osteoarticular manifestations from the age of 13: pain and functional impotency of the left limb, past femoral fracture, kyphoscoliosis and facial asymmetry. The patient had also episodes of tachydysrhythmias. Laboratorial tests revealed hypophosphatemia, hyperphosphaturia, elevation of serum bone markers and primary hyperthyroidism. The imaging studies showed multiple FD areas and several bone deformities. The most frequent GNAS somatic mutation was not detected in four different types of tissue studied. The patient was managed with bisphosphonates, calcitriol and oral phosphate, with significant improvement. The hyperthyroidism was treated with radioiodine. Discussion: We reported a MAS case with multiple endocrine and non-endocrine disease manifestations. The osseous disease is commonly the most prominent feature. Our patient had a unique fast-growing and infiltrative breast benign neoplasia, emphasizing the possible association of breast disorders in this setting. Genetic testing, not routinely available, may contribute little to the diagnosis and to the patient management.