Human body is a biological, open system and maintains itself in the changing environment. Disease state is cured by many medicinal systems for healing. Esoteric healing (through introspective hypnosis, meditation and spiritual intercession) is the system where its believers regard Supreme Being as Omnipotent, Omnipresent and Omniscient. Such persons take ill health as a boon and pray through meditation that He may by His Mercy grant health or if God wishes otherwise, they happily accept it so that they keep moving ahead on their spiritual path. This study is a review of literature, where results clearly point towards better psychological and spiritual healing in patients who believe in esoteric cures. Modern science in terms of cognitive psychology or neurophysiology has begun to emphasize the role of consciousness but, that is confined only to the physical world. It is only with the advent of Param Purush Puran Dhani Soami Ji Maharaj (200 years ago) that in the religion of Saints, the ultimate consciousness or the Super Consciousness of the highest order has been revealed.

Disease and sufferings lead religious persons nearer to almighty in search of mercy. Not much is known about how to design and disseminate programs of spiritual exercises and spiritual indicators for persons suffering with some disease (sufferers). Research is required to advance the understanding of prioritized internal and external indicators responsible for spiritual awakening among these sufferers. In this paper, an attempt is made to compute OFDP (overall futuristic decision priority) weights to generate spiritual scenarios for spiritual awakening by using MCFDM (multi-criteria futuristic decision-making) methodology. The generated prioritized spiritual scenarios responsible for spiritual awakening among sufferers were then used to assess the effect of some kind of disease (physical problem, suffering, disorder, etc.) on strengthening their religious faith and defining their optimal spiritual trajectories towards ultimate reality. In this research work, a two-phased DRFI (disease-religious faith-interaction) experiment is also designed and developed. The results derived from Phase-I pilot research study based on prioritized spiritual scenarios on 20 male and female sufferers are also presented.