Human body is a biological, open system and maintains itself in the changing environment. Disease state is cured by many medicinal systems for healing. Esoteric healing (through introspective hypnosis, meditation and spiritual intercession) is the system where its believers regard Supreme Being as Omnipotent, Omnipresent and Omniscient. Such persons take ill health as a boon and pray through meditation that He may by His Mercy grant health or if God wishes otherwise, they happily accept it so that they keep moving ahead on their spiritual path. This study is a review of literature, where results clearly point towards better psychological and spiritual healing in patients who believe in esoteric cures. Modern science in terms of cognitive psychology or neurophysiology has begun to emphasize the role of consciousness but, that is confined only to the physical world. It is only with the advent of Param Purush Puran Dhani Soami Ji Maharaj (200 years ago) that in the religion of Saints, the ultimate consciousness or the Super Consciousness of the highest order has been revealed.

Introduction: To evaluate the effects of intraovarian platelet-rich plasma (IOPRP) instillation in young Indian women with diminished ovarian reserve (DOR). Methods: This prospective, ongoing, cohort study was performed by recruiting 45 consenting Indian women with DOR (group A). Up to 3 cycles of IOPRP instillation were performed after minimal ovarian stimulation. Outcome measures were changes in antral follicle counts (AFC), anti-Müllerian hormone (AMH) levels, an increase in total and mature oocytes retrieved and establishment of pregnancy. The pregnancy rates in 51 women with the same inclusion criteria during the same time period were compared (group B). Results: In group A, baseline mean AFC was 3.44±2.35 (n=45); mean AFC increased after IOPRP-1 (3.89±2.21, n=45, P=0.1198<0.05 vs. baseline), IOPRP-2 (4.91±2.79, n=33, P=0.0056<0.05 vs. baseline), and IOPRP-3 (4.95±2.84, n=19, P=0.0002<0.05 vs. baseline). Mean AMH was 0.85±0.44 ng/mL. The changes in average AMH levels showed significance after IOPRP-2 (P=0.048<0.05). In group B, mean baseline AFC was 4.74±2.19, mean baseline AMH was 0.98±0.38 ng/mL. In group A, frozen embryo transfer was performed in 32/45 women and 15 clinical pregnancies were established. In group B, 44/51 women underwent frozen embryo transfer, 11 clinical pregnancies were established. The clinical pregnancy rate per transfer was 46.88%/embryo transfer in group A versus 25%/embryo transfer in group B. Conclusions: IOPRP instillation can improve AFC and can enhance pregnancy results in women with DOR. Increase in AMH levels and the number of total and mature oocytes was observed after 2 IOPRP. Significantly higher pregnancy rates (P=0.0009<0.05) were observed in women with IOPRP versus matched controls without IOPRP.

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Problem Diagnosis of female genital tuberculosis (FGTB) remains elusive due to the paucibacillary nature of the disease. We evaluated if analysis of inflammatory pathways of endometrial tissue could establish a better diagnosis of FGTB. Method of Study One hundred and four infertile women suspected of having GTB or having been treated for GTB in the past, underwent endometrial biopsies for diagnosis and Gene Inflammatory Pathways analysis at our center between 2018–2020. Diagnosis of FGTB was based on acid‐fast bacilli culture, immunocytochemistry, nested‐polymerase chain reaction, histopathological examination, TB GeneXpert, or combinations thereof. Gene expression profiles were also analyzed. Results Based on diagnostic tests of 104 women, 44 (42%) were considered TB‐positive, 35 (34%) TB‐negative, and 25 (24%) TB‐negative after TB treatment in the past. Inflammatory pathways were significantly upregulated in TB‐positive women versus TB‐negative (41% vs. 6%; p = .0005), and in women who were TB‐negative after TB treatment in the past versus TB‐negative (never treated for TB in the past) (38% vs. 6%; p = .0037). Two‐hundred seventy‐one genes were upregulated, and 61 genes were downregulated in TB‐positive women versus those who were TB‐negative. Differentially expressed genes were mapped to various interlinked inflammatory signaling pathways, including mitogen‐activated protein kinase (MAPK), Natural Killer (NK) cells, nuclear factor kappa‐B (NF‐kB), tumor necrosis factor (TNF), and Toll‐like receptors (TLR) signaling. Conclusions Inflammatory pathways and gene expression profiles add to the diagnostic tools to identify TB‐positive women at an early stage. The results from this study are still experimental and large multi‐centric studies are suggested before their recommendation in routine clinical practice.

RESULTS: For 23 embryos diagnosed as aneuploid by initial TE biopsy, 78.3% of initial TE samples, 87.0% of TE re-biopsies and 78.3% of BCM samples were concordant with corresponding ICM samples (P>0.05); but for 3 mosaic embryos, the concordance rates with ICM of these three groups were 0%, 100% and 100% (P<0.05), respectively. With the corresponding ICM result as the true result, sensitivity of both niPGT-A and initial TE were 100%; but the FPR of initial TE was higher than that of niPGT-A (100% vs. 0, P¼0.100).CONCLUSIONS: NiPGT-A using spent BCM had similar diagnostic efficiency as TE-biopsy PGT-A. And in case of mosaic embryos, niPGT-A using BCM may be more reliable for predicting the karyotypes of ICM than initial TE biopsy.