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Pyrimidine is a heterocyclic aromatic organic compound which is versatile lead compound for designing potent therapeutic agents. Different pyrimidine derivatives have been synthesized by various conventional methods and also from green methods. The pyrimidine moiety widely occurs in biologically occurring compounds, such as nucleic acids components, folic acid and vitamin B1 etc. This compound has various biological activities like anticancer, antitubercular, antimicrobial, antifungal, antibacterial, antioxidant, anticonvulsant, analgesic, CNS depressant, anti-inflammatory, anti-HIV, antihelmentic and herbicidal activity. Available data represents pyrimidine being heterocyclic six membered ring systems has various pharmacological actions and synthesis of pyrimidine and their derivatives are discussed. CONTENTS 1. INTRODUCTION 2. SYNTHESIS OF PYRIMIDINE 2.1 CONVENTIONAL SYNTHESIS OF PYRIMIDINE 2.2 GREEN SYNTHESIS OF PYRIMIDINE 3. MEDICINAL SIGNIFICANCE OF PYRIMIDINES 3

The vanadyl(IV) complexes of substituted chalcones were prepared by refluxing vanadyl sulphate with different substituted chalcones in ethanoic medium. The chalcones were prepared with different aromatic aldehydes like benzaldehyde, hydroxy benzaldehyde, nitro benzaldehyde and chloro benzaldehyde. The synthesized Vanadium complexes were characterized by different spectral techniques. The IR spectral studies revealed that the chalcone derivatives are bidentate ligand. Magnetic studies, electron spin resonance and UV studies suggest that the complexes are in square pyramidal geometry. Conductance measurements suggest that all complexes are non-electrolyte in DMF. The thermal study explained the stability of complex and its decomposition. The synthesized ligand and metal complexes were screened for their antibacterial activity against E. coli and Staphylococcus aureus bacterial strains and for antifungal activity against P. notatum.