No abstract

In the course of a screening for cytotoxic compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC 50 -values of 0.5ϳ3 mg/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).

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The new heterocyclic spiro terpenoid niveulone (1) was isolated from the cultural fluid of the ascomycete Dasyscyphus niveus, and its chemical structure and relative configuration were determined by spectroscopic techniques.

No abstract