The higher education institutions play a very important role in developing the readiness of academic staff on IR 4.0 which might increase the quality of education system through implementing the effective learning factors, efficiency knowledge management factors, and creative thinking with the innovation capability. Here, the academic staff must further explore the new knowledge, innovation, and learning factors that could be used in their teaching and learning. The research model was taken from previous studies on examining the feasibilities of Industry 4.0 for the hospitality sector with the lens of management practice. The data was analyzed by using the IBM SPSS Statistics v21 and the five-point Likert scale represented by Information Literacy Education Implementation Readiness Scale was used to measure the respondents' readiness level on IR 4.0. Descriptive analysis than was used in this research to further explore the mean factors which are learning, knowledge management and innovation capability, and the academic staffs' readiness for IR 4.0.. The results indicated that the learning institutions played a very important role in developing the readiness of academic staff on IR 4.0 which may increase the quality of education system through implementing the effective learning factors, efficiency knowledge management factors and creative thinking with innovation capability factors.