The yellow pigment of turmeric (Curcuma longa) i.e. Curcumin (diferuloylmethane has been associated with a number of properties such as antioxidant, anti-inflammatory, neurotrophic activity, antibacterial, antiviral, and anticancer etc. Oxidative stress is believed to be one of a major contributing factor for teratogenesis (congenital birth defects). However, enhanced oxidative stress may cause irreversible embryonic and foetal damage. However, Curcumin attracted attention due to its promising actions but limited bioavailability and inability to detect Curcumin in circulation or target tissues has causing hindered in the validation of a causal role. Here, we discuss the various scientific article enhance their activity by the improving their in intriguing form like nonoparticle complex or with supplementation or in encapsulated form making its importance advance in the treatment of various ailments rather than congenital birth defects also.

Herb is very crucial valued for its medicinal, aromatic or slavery qualities that contains a variety of chemical substances that act upon the body to prevent relieve, and treat illness. The herbal medicine has a long and respected history. The Alpinia zerumbet Roxb. are used as analgesic, anthelmintic, blood purifier, carminative , demulcent , diaphoretic , diuretic, expectorant, febrifuge, purgative, sedative, anti-inflammatory, cardiovascular etc a number of other ailments. In Brazil, A. zerumbet is one of the most cited plants for folk medicine and it has been suggested for use by Brazil's public health system (SUS). The current work focuses the properties of these plants and open gate for the further exploration in future of these plants due to a number of good medicinal values for human welfare.

Valproic acid (VPA) is widely used as an anticonvulsant and mood-stabilizing drug. It is highly prescribed drug, particularly for epilepsy. However, besides beneficial VPA have a number of side effects due to affecting several signaling pathways through different mechanisms. VPA act as a potent teraogen causing birth defects via interfering with folate metabolism or oxidative stress generation, and histone deacetylase inhibition. However, this article aims to give an overview of the these adverse consequences of VPA are significantly curtailed by the various substances like Vitamin E, Ascorbic Acid, Folic acid, Pantothenic acid, S-adenosyl methionine (SAM) and Curcumin etc which can be focus on its therapeutic use in future against it because of no such other alternative.