Background: The use of electronic cigarettes is one of the current public health problems on increasing alert, has been growing at an accelerating rate, and has become a public health emergency. Its importance is explained by the continuous growth and acceleration of oncological rates among all ages versus the absence of high-quality evidence, correlated to the use of nicotine derived products, being at their regular versions or the new ones. Available preclinical data indicate that activation of the sympathetic nervous system by nicotine inhaled from e-cigarettes may stimulate cancer development and growth by several mechanisms, which results can significantly reduce life's quality. This systematic review and meta-analysis protocol aims to clarify the connection between the use of electronic cigarettes by adults over the age of 18 and the development of malignant neoplastic diseases.Method: The proposed systematic review and meta-analysis will be reported conforming to the preferred reporting items for systematic reviews and meta-analyses guidelines. Will include the following studies: case-control or cohort studies showing adults (18 years old age) using e-cigarettes. There will be no language or publication period restrictions. Articles published, but not peerreviewed, will not be included in the review. Data will be entered in the Review Manager software (RevMan5.2.3). For dichotomous outcomes, we extracted or calculated the OR and 95% CI for each study. In case of heterogeneity (I²>50%), the random-effects model will be used to combine the studies to calculate the OR and 95% CI.

Introduction: Religiosity and mystical experiences accompany society throughout history, integrating its identity formation. Neuroscience unveils neural correlations, maps the areas involved and activity patterns, and functional magnetic resonance imaging (fMRI) is applied to detect variations in activation of neural activity. Objectives: Thus, the objective is to understand the neurophysiological differences between individuals who experience religiosity and the mystical experiences of those without, through the fMRI. Methods: This literature review, collected data in April/2021 on Medline, Pubmed and Science Direct. The descriptors used, after consulting the MeSH, consisted of “neural correlates of religious”, “mystical experience” and “functional magnetic resonance imaging (fMRI)”. Were found 227 articles, after applying the exclusion criteria and fully reading of the abstract, the sample included 6 articles in English, from the last 10 years, available in full text, 2 Medline, 3 Pubmed and 1 Science Direct. Results: The consensus was reached that religiosity can be grounded by neural factors, by applying fMRI to identify patterns of activation of brain regions during mystical experience, although one of the articles refutes these relationships. Correlations are cited by regions: frontal and temporal - emphasis on the dorsolateral and medial/superior prefrontal cortex and bilateral lower parietal lobes, as promoters or impeders of the religious profile in individuals, due to the negative regulation due to lack of excitement, injuries or structural changes. Conclusions: It is concluded that the neurophysiological findings were able to detect patterns that can serve as eligibility criteria between believing and non- believing individuals, which makes their subsequent application feasible for better clarification and neural distinction.

No abstract