Obesity, broadly refers to increased body fat, which has become an important public health problem. Its prevalence continues to increase worldwide. In the World Health Survey, the prevalence of physical inactivity in India was 9.3% in men and 15.2% in women. Adipose tissue being an endocrine organ secretes several cytokines such as Interleukin-6, TNF-α and adipokines such as adiponectin, hepcidin, resistin. This study is to compare ferritin to iron and hepcidin with normal and obese men. This case-control study was conducted at a multispecialty centre in Chennai, Tamil Nadu between 2013 and 2015, including 80 subjects of South Indian population. The biochemical parameters which were measured included the levels of hepcidin, ferritin, iron, Total Iron Binding Capacity and Hemoglobin. The results were statistically analyzed. Mann whitney U test performed to check for the statistical significance for differences in mean between the groups. The mean hepcidin values for the control group was 800.55 ± 503.50 and the study group was 1106.68 ± 826.25 and was found to be statistically significant with a p-value of 0.03. There was positive correlation of hepcidin with ferritin and Transferrin Saturation. Hepcidin is recognized as the key regulator of systemic iron homeostasis. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.

Triglyceride-Glucose (TyG) index is an independent predictor of cardiovascular risk in several pathological conditions such as T2DM, Metabolic syndrome (MetS), CVD, and CAD. Early studies which were done on TyG index focus on insulin resistance. High TGL level induces production of small density LDL particle. All these proposed theories, explains why TyG index used as an independent factor of cardiovascular risk.150 First year medical students were included and their anthropometric measures done using standard scale. Fasting blood glucose estimated by GOD POD method. Total cholesterol, triglyceride, High density lipoprotein and direct low density lipoprotein were estimated by IFCC approved methods. Statistical analysis was performed using IBM SPSS version 20.Results 26% were obese and 5.33% were overweight. Lipid profile found to be significant different among the group. Atherosclerotic indices were found to have mild to moderate correlation with anthropometric measures (p < 0.05).Present study showed a high prevalence of overweight to obesity ratio in first year medical students. With TyG index we observed an independent association of cardio-metabolic risk with BMI in young adult.