Cancer is an unprecedented proliferation of cells leading to abnormalities in differentiation and maturation. Treatment of primary and metastatic cancer is challenging. In addition to surgery, chemotherapy and radiation therapies have been conventionally used; however, they suffer from severe toxicity and non-specificity. Immunotherapy, the science of programming the body's own defense system against cancer has gained tremendous attention in the last few decades. However, partial immunogenic stimulation, premature degradation and inability to activate dendritic and helper T cells has resulted in limited clinical success. The era of nanomedicine has brought about several breakthroughs in various pharmaceutical and biomedical fields. Hereby, we review and discuss the interplay of tumor microenvironment (TME) and the immunological cascade and how they can be employed to develop

Almraet. N-(thiophene-2-carboxamido) salicylaldimine (H2TCS) reacts with lanthanide chlorides in the presence of KOH to give complexes of the type K(Ln(TCS)2 ] [Ln = La(IlI), Pr(lll), Nd(III), Sm(lll), Eu(III), Gd(lll) and Dy(IIl)]. A tentative structure for these complexes has been suggested on the basis of molar conductance, TGA and DTA, magnetic" susceptibility, electronic, infrared and 1H and laC NMR data. The nephelauxetic ratio (~), covalency ( 6) and bonding parameter (b1/2) have been calculated from the electronic spectrum of the Nd(III) complex. A coordination number of six around the metal ion has been suggested. Keyworda. Lanthanide chlorides; N-thiophene-2-carboxamidosalicylaldimine complexes; tridentate ligand; hexa-coordinated lanthanide complexes.

In the original publication of the article, the third author name is corrected from "Akhilesh." to "Akhilesh". The original article has been corrected.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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