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Objective:The aim was to study the effect of short-term Yoga therapy program on quality of life in patients suffering from psychosomatic ailments.Methods:Sample size and Study period: All the subjects coming to SVYASA AROGYADHAMA in month of July 2011 for Yoga therapy for various psychosomatic ailments and were free of any primary psychiatric illness and volunteering to participate were enrolled in the study after taking informed consent. Their physical condition was healthy enough to practice Yoga as judged clinically. All subjects (n = 94) who were enrolled in the study underwent Integrated Approach to Yoga Therapy, which included Asanas, Pranayamas, meditation, Kriyas and lectures on practice of Yoga and derived special techniques in their respective sections. The quality of life was assessed by SF-12 questionnaire and thereby calculating Physical and Mental Composite Scores (PCS and MCS) before and after 1 week of Yoga therapy. Data thus obtained was analyzed using paired t-test.Results:A significant improvement (P < 0.001) was seen in the study group in both PCS (from mean ± SD of 37.50 ± 9.58 to 43.7 ± 8.73) and MCS (from 45.87 ± 9.57 to 53.35 ± 7.9.) with minor variations in patients of various departments.Conclusion:A short-term Yoga therapy program leads to a remarkable improvement in the quality of life of the subjects and can contribute favorably in the management of psychosomatic disorders.