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The solubilities of 6-aminopenicillanic acid and phenoxyacetic acid were determined at 25°C in aqueous solutions of several hydrotropes by the weight disappearance method at different hydrotrope concentrations. Commercially available aqueous hydrotrope solutions employed were 50 mass % sodium butyl monoglycol sulfate, 40 mass % sodium cumenesulfonate, 40 mass % sodium xylenesulfonate, and 40 mass % potassium-sodium xylenesulfonate, all the hydrotrope concentration mass percentages being expressed on a mass/mass basis. At high concentrations, above the threshold hydrotrope concentration, hydrotropes enhance the solubilities of these components differently. The ternary solid-liquid phase equilibrium diagram for the 6-aminopenicillanic acid-phenoxyacetic acid-water system with sodium butyl monoglycol sulfate as a hydrotrope was constructed. Solubilities of 6-aminopenicillanic acid were also determined in the reaction product mixture with or without the 30 mass % sodium butyl monoglycol sulfate hydrotropic medium. A medium of aqueous sodium butyl monoglycol sulfate solution can be used for the better separation of 6-aminipenicillanic acid.

The solubilities of m-and p-aminoacetophenones were determined in aqueous solutions of several hydrotropes by the weight disappearance method at different hydrotrope concentrations and temperatures. Commercially available aqueous hydrotrope solutions employed were 50% sodium butyl monoglycol sulfate, 40% sodium cumenesulfonate, 40% sodium xylenesulfonate, 40% sodium toluenesulfonate, and 40% ammonium xylenesulfonate, all the hydrotrope concentrations being expressed in mass/mass. At high concentrations, above the threshold hydrotrope concentration, hydrotropes enhance the solubilities of these components differently. The differences in solubilities with hydrotrope concentration and temperature can be exploited for the separation of these isomers.

A lemary rolid-llqukl dlagram of the ryrtem p c r e d , 2,6xyknd, and f.ri-bulyl alcohol b prepared. f i -B u l y i alcohol can be used as an extraneous agent for the uparatlon of p-crerd from ilr mlxture with 2,6xylenoi by adductlve cryrtallltallon in a muilktage process, both of these compounds being close-boiling componenls of the mlxture.

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