HPMC K4M, HPMC K15M, and HPMC K100M polymers are used in this study to make floating tablets of famotidine hydrochloride. Drug Delivery systems that are floating in the stomach have a lower bulk density than gastric fluids, therefore they stay buoyant in the stomach for a lengthy period of time without impacting gastric emptying rate. In the treatment of gastroesophageal reflex disease (GERD) and peptic ulcer (PUD). Famotidine is a histamine H2 receptor antagonist (GERD). Famotidine is an excellent option for a floating drug delivery system because of its short half-life, brief time in the stomach, and repeated doses. Melt-granulation technique was used to make famotidine floating tablets using HPMC K4M, HPMC K15M, and HPMC K100M. In vitro buoyancy, drug polymer compatibility (IR Research), weight fluctuation, hardness, friability, thickness, drug content and invitro dissolution experiments were all performed on the floating tablets. Using in vitro buoyancy and dissolvability experiments, we were able to establish that the micromeritic characteristic were excellent. HPMC K100M-based formulation F4 has an excellent in vitro buoyancy lag time and floating time, and in vitro dissolution investigations demonstrate a 96.78 percent release for 12 hours. As a result of the findings of this research, it can be concluded that famotidine floating tablets provide the potential for longest- term drug delivery and a consequent reduction in dosage frequency.
Keywords: Gastroretentive floating tablet, Famotidine, Formulation and Evaluation, Biopolymer
The disposal of fly ash from thermal power plants is becoming a serious concern for environmental engineers. This article attempts to study the influence of particle size of the fly ash on the various properties of high concentrated slurry (50 - 70 % by weight) flow through a horizontal pipe with the help of a commercial CFD code ANSYS FLUENT. Modified Herschel-Bulkley model and SST k-ω turbulence model is used for computational analysis, and the computational outcomes are validated with the available literature. In the present study, the fly ash samples were procured from different coal-based thermal power plants. Various properties: physical and rheological are obtained experimentally. The specific gravity of particles and the static settling concentration (SSC) of the slurry increases with the decrease in the particle size. The rheological properties increase as the concentration increases, and the slurry behaves like a non-Newtonian fluid at a high concentration. In addition, the particle size and concentration intensively impact on the skin friction coefficient and velocity distribution. However, no significant impact on the velocity profile at 70 % concentration (by weight).
HIGHLIGHTS
The rheological properties increase as the concentration increases, and the slurry behaves like a non-Newtonian fluid at a high concentration
CFD modelling of the slurry flow at high concentration with modified Herschel-Bulkley model and SST k-ω turbulence model
The particle size and concentration intensively impact on the skin friction coefficient
GRAPHICAL ABSTRACT
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