Formulation and Evaluation of Famotidine Gastroretentive Floating Tablet by Using Biopolymer

Abstract

HPMC K4M, HPMC K15M, and HPMC K100M polymers are used in this study to make floating tablets of famotidine hydrochloride. Drug Delivery systems that are floating in the stomach have a lower bulk density than gastric fluids, therefore they stay buoyant in the stomach for a lengthy period of time without impacting gastric emptying rate. In the treatment of gastroesophageal reflex disease (GERD) and peptic ulcer (PUD). Famotidine is a histamine H2 receptor antagonist (GERD). Famotidine is an excellent option for a floating drug delivery system because of its short half-life, brief time in the stomach, and repeated doses. Melt-granulation technique was used to make famotidine floating tablets using HPMC K4M, HPMC K15M, and HPMC K100M. In vitro buoyancy, drug polymer compatibility (IR Research), weight fluctuation, hardness, friability, thickness, drug content and invitro dissolution experiments were all performed on the floating tablets. Using in vitro buoyancy and dissolvability experiments, we were able to establish that the micromeritic characteristic were excellent. HPMC K100M-based formulation F4 has an excellent in vitro buoyancy lag time and floating time, and in vitro dissolution investigations demonstrate a 96.78 percent release for 12 hours. As a result of the findings of this research, it can be concluded that famotidine floating tablets provide the potential for longest- term drug delivery and a consequent reduction in dosage frequency. Keywords: Gastroretentive floating tablet, Famotidine, Formulation and Evaluation, Biopolymer

Phytochemical Screening, Antioxidant and Antibacterial Properties of Extracts of Viscum continuum E. Mey. Ex Sprague, a South African Mistletoe

“…These compounds can also be found in other species of plants from the same family of Viscum, as per previous reports [46][47][48]. The identified phytochemicals are associated with various biological properties, such as but not limited to antiseptic, antioxidant, antibacterial and anticancer effects, as well as other immune-boosting benefits [31][32][33]. These are important biological properties to be associated with a plant found in a developing country, where about 60% of the population relies on medicinal plants to treat various diseases.…”

“…This does not come as a surprise, since related species have already been explored for possible cancer treatments. Although to a varying degree all extracts showed the presence of phenolic compounds as well as tannins, the phenolic compounds are mainly known to be responsible for their antiseptic, anti-inflammatory, antioxidant as well as anti-cancer properties of Mistletoe plants [31,32]. This suggests that all the South African Mistletoe tree extracts should have some degree of antioxidant activity in addition to the other activities.…”