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Vidyabharati college of Pharmacy,Amravati, India. Corresponding author*: vivekp62@gmail.comThis article is available online at www.ssjournals.com ABSTRACTIn recent times, focus on plant research has increased all over the world. Acorus calamus is an important medicinal herb that is widely used. B asarone primary constituents Acorus calamus are manly believed to be responsible for its wide therapeutic actions. (Acorus calamus L., Araceae) is an aromatic herb, indigenous to Central Asia and Eastern Europe. The fragrant oils obtained by alcoholic extraction of the rhizome are mainly used in the pharmaceutical and oenological industries. Different parts of the plant showed the presence of large number of phenyl propanoids, sesquiterpenes and monoterpenes as well as xanthone glycosides, flavones, lignin lignans, steroids and inorganic constituents Alcoholic extracts of the triploid A. calamus were characterized by a higher percentage of b-asarone (11%), which was the main compound, followed by higher percentages of camphene (2.27%), E-bocimene (3.28%), camphor (1.54%), calarene (1.42%), a-selinene(5.02%) and s-cadinol (2.00%), when compared to the diploid A. calamus. The latter had higher percentages of isoshyobunone(8.62%), b-sesquiphellandrene (3.28%), preiso calamendiol (22.81%) and acorone (26.33%), and completely lacked of b-asarone. It is also reported to possess insecticidal, lucicidal, anti-inflamatory, antibacterial, antiulcer radioprotective, antispasmodic, bronchodilatory, glucosidase inhibitory, insulin sensitizing, antiepileptic, anticholinestrase, larvicidal, antibacterial, mutagenic, anticonvulsant, neuroleptic, smooth muscle relaxant and smooth muscle stimulant activity.

In the present investigation, the saponins rich fraction of roots of Cassia auriculata L. was evaluated for antimicrobial activity against P. vesicularis, Streptococcus faecalis, Aeromonas hydrophilia, Salmonella typhae, Staphylococcus cohni, Serratia ficaria and E. coli at concentration of 12.5 mg/ml, 25 mg/ml, 37.5 mg/ml and 50 mg/ml. Antimicrobial activity of Cassia auriculata L. was carried out by well diffusion method. At maximum conc. i.e. 50mg/ml, antimicrobial effect of Saponin rich extract can be arranged in sequence of - P. vesicularis > Serratia ficaria > Streptococcus cohni > Aeromonas hydrophilic> Salmonella typhae > Sterptococcus faecalis > E. coli. The results indicate the saponins rich fraction of roots of Cassia auriculata L. might be exploited as natural drug for the treatment of several infectious diseases caused by these organisms. Cassia auriculata L. was observed to have antibacterial activity and can be used for medicinal purposes.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14056 International Current Pharmaceutical Journal, March 2013, 2(4): 85-87

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Objective:To determine antimutagenic activity of Cassia auriculata Linn. on chromosomal damage induced by cyclophosphamide (CP).Material and Methods:In the present investigation, four groups of six Swiss albino mice in each group were used. Excepting for thefirst group all the remaining groups were treated with CP (50 mg/kg). Mice of third and fourth group were treated with ethyl acetate extract of C. auriculata Linn. at 100 mg/kg and 200 mg/kg with CP. Metaphase of bone marrow cells of all animals were analyzed for qualitative and quantitative chromosomal aberrations. Break, fragment, deletion, Polyploidy, pulverized, ring and total aberration were observed.Results:Flavonoids rich extracts of root of C. auriculata Linn. provided significant protection (P < 0.05) against CP induced chromosomal aberration. Total chromosomal aberration was found to be 12.16 and 7.33% in 100 and 200 mg/kg of extract treated animals respectively.Conclusion:From the present study it can was observed that ethyl acetate extract of C. auriculata Linn possess significant anti-mutagenic potential against CP induced chromosomal aberration.