Background: Tuberculosis is a disease caused by Mycobacterium tuberculosis. Indonesia ranks second worldwide in TB incidence in the country. Content: The spread of the disease is happening across Indonesia. Each area of Indonesia had different types of lineage M. tuberculosis and TB incidence number. Drug resistance is threatening to society and it needs full attention and immediate medication to control the disease. Therefore, this paper is composed of reviews from 10 journals that reported drug resistance TB in several different locations in Indonesia using different methods available. Conclusion: The number of TB cases and their lineages differ in each area in Indonesia, one of which is due to the availability of diagnostic tools and level of self-awareness in each area. There are reported findings of drug resistance TB in Indonesia that are concerning. Currently, many TB treatments are under development to produce the best therapy to treat the disease.

Hypercholesterolemia is a condition that affects cholesterol levels because of the increase of LDL. Hypercholesterolemia is connected to atherosclerosis disease, which causes the blockage of blood flow. Naringin is a flavonoid primarily found in the citrus family and proved to have various benefits, one of which is antiatherogenic. The article searching was done in PubMed, Wiley Online Library, Cochrane, ProQuest, ScienceDirect, and Google Scholar databases. The final three studies about naringin supplementation in animals models are assessed. Naringin had an antiatherogenic effect and decreased the aorta lesion in atherosclerosis by several different mechanisms.

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance. Medication for T2DM mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking, thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.

Nauclea orientalis L. is widely distributed in Indonesia. Secondary metabolites such as flavonoids, polyphenols, and saponins are abundant in the bark of N. orientalis L. These compounds have the potential to act as antioxidants. Endophytic fungi, through genetic transfer and coevolution, can produce the same metabolites as their host plant. As a result, understanding the potential of endophytic fungi from N. orientalis L. to produce antioxidant compounds that can be developed is critical. According to the findings of this study, twelve isolates have the potential to produce secondary metabolites with antioxidant properties. Three isolates had high antioxidant activity: DB2 was identified as Aspergillus minisclerotigenes with an IC50 of 21 g/mL containing tannins, terpenes, and flavonoids, AB3 as Colletotrichum perseae with an IC50 of 31 g/mL containing tannins and terpenoids, and AB1 as Diaporthe tulliensis with an IC50 of 48 g/mL containing tannins. The secondary metabolite group has the potential to be developed into an antioxidant agent