No abstract

Introduction. Multiple pathogenic mechanisms are found in SARS-CoV2 systemic inflammation. Oxidative stress, altered proteolysis, hypercoagulation, and metabolic disorders are significant in virus-induced lesions. The study aimed to investigate the biochemical mechanism of virus-induced disorders and determine the biochemical features in SARS-CoV2-associated liver damage and intestine lesions. Methods. A retrospective case series of ninety-two patients diagnosed with COVID-19. The ACE, α1-proteinase inhibitor, trypsin-like proteinase, and elastase activity were measured by FAPGG hydrolysis. Nitrites level was detected in reaction with Griess reagent. The ELISA kit measured Troponin, C-peptide, leptin, adiponectin, PAR4, and neuropilin level. Results. ACE activity and nitrites ions content increase in SARS-CoV2 pneumonia. The hyperglycemia with an increase in adipose tissue-derived hormones is specific for virus-induced disorders and affects the development of unfavorable outcomes. Cardiac failure was detected in patients with ARDS. AH patients with COVID-19 had more pronounced hyperglycemia and increased ACE activity and NO ions level. Activation of proteolysis was revealed in SARS-CoV2 pneumonia. The found molecular event was accompanied by hyperglycemia induction. Liver damage was specific for patients co-infected with COVID-19 with severe ARDS and heart failure. But the intestinal lesions were associated with the proteolysis activation. The obtained data shows the prevalence of the neuropilin-dependent axis in damage of the intestine with more pronounced inflammation. Growth in adipose tissue hormones, nitrites, and neuropilin levels is triggered by prolonged inflammation. Conclusions. The impaired metabolism, SARS-CoV2 associated hyperglycemia influence on SARS-CoV2 multiple mechanisms of virus invasion. Gastrointestinal manifestations in SARS-CoV2 infection are related to various and varied tools. ACE2 receptors axis is prevalent for liver damage, but NRP-1 protein (neuropilin), NO derivatives, and adipose tissue-derived hormones are essential for intestinal lesions.

The widespread infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) significantly impacts major human diseases. It is undoubtedly evident that cancer patients are more susceptible to the infection and at a higher risk of severe COVID-19 than the general population. Moreover, the rise in cancers incidence is waiting in the Globe as a long-term effect of post-COVID-19 complications. Multiple mostly unknown mechanisms participate and determine the oncogenic impact of virus-induced transformation. Imbalance in oncogenesis is considered critical in cancer development. Modified immunogenicity and metabolic features emerge as pivotal in COVID-19 pathogenesis and the organism system's response. The molecular mechanisms of the onset of the metabolic disorder have not yet been fully elucidated. The pathology is complicated, multifactorial, and emerging in various processes. Preventive anticancer therapy taking into account the change in metabolic processes, helps them respond better to anti-COVID-19 treatment than relying only on antiviral drugs. The modified therapeutic algorithm was provided to reduce the likelihood of post-acute complications in patients with preexisting pathologies and the onset of other chronic pathologies and cancers.