Посттравматическое стрессовое расстройство (ПТСР) -это симптомокомплекс, наблюдающийся у лиц, переживших травматический стресс. Патофизиология ПТСР связана с преобладанием процессов перевозбуждения. Предположительно, в основе патологических изменений при ПТСР лежит феномен эксайтотоксичности. Последствием эксайтотоксичности является оксидативный стресс (ОС). Исследовали возможность коррекции ОС путём применения органического Se у пациентов с риском развития пост-травматического стресс-синдрома. Проспективное рандомизированное исследование, проведённое у лиц Латвийского контингента международных операций до и после участия в миротворческой миссии, показало, что у пациентов, принимавших Se, степень выраженности клинической симптоматики ПТСР, определяемой в пунктах анкеты PCL-M, снизилась на 5,85% по отношению к исходному, а также на 46,03% по отношению к исходному снизилась распространенность ПТСР (Prevalence Rate). Выявлена статистически значимая корреляция между параметрами ОС, распространённостью ПТСР и клинической выраженностью симптомов ПТСР.Ключевые слова: селен, оксидативный стресс, эксайтотоксичность, посттравматическое стрессовое расстройство.

Chronic kidney disease (CKD) is a major public health concern. Despite many potentially life-threatening conditions that can accompany kidney disease, cardiovascular disease (CVD) remains the leading cause of death in these patients. Adjusted-for-age mortality from CVD in patients with end-stage renal disease is 10-30 times higher than in the general population. A decrease in renal function accelerates the development of cardiac pathology. Simultaneous exposure of CVD and CKD plays an important role in the relationship between arterial stiffness (AS) and estimated glomerular filtration rate. But there is a controversy as to whether the AS causes deterioration in kidney function, if renal dysfunction leads to AS, or the relationship is reciprocal. Hence, several studies that recruited high-risk populations reached a conclusion that comorbidities might lead to both AS and decline in kidney function over time. A number of studies have shown that several markers of AS, such as pulse pressure, central and peripheral pressure are associated with the development of CKD. This review takes into account the theoretical background, current status, and future potential of the techniques that measure AS within context of CKD assessment and management.

IntroductionThe Posttraumatic Stress Disorder (PTSD) Checklist (PCL) is a 17-item self-report measure of the 17 DSM-IV symptoms of PTSD. The PCL has a variety of purposes, including screening individuals for PTSD, diagnosing PTSD, monitoring symptom change during and after treatment. There are three versions of the PCL: PCL-C (civilian), PCL-M (military) and PCL-S (specific). PCL-M asks about symptoms in response to “stressful military experiences” and used for active service members and veterans. The PCL-M can be completed by participants of a research study in approximately 5–10 minutes. Interpretation of the PCL-M should be completed by a clinician. There is no valid PCL-M Latvian language version.AimsThe goal of the study is to assess the evaluative and discriminative properties of the Latvian language version of the PCL-M in PTSD risk group patients (PTSD-RGP).MethodsTotally 30 participants (males, Europeans, of average age 26.2, PTSD-RGP - Latvian Contingent of International Operations) were examined. Standart validation protocol was applied for PCL-M Latvian language version's reliability and validity testing: reliability consequence, construct validity, test-retest, Cronbach alpha criterion.ResultsCronbach alpha criterion was more than 0,70 (means reliable response sets), the reliability-consequence scale is from 0.6 to 0.9 (means precise definition). Test-retest by Spearman showed r ≥ 0.75 (means reliable stability).ConclusionsIt was concluded that the PLC-M Latvian language version has sufficiently acceptable evaluative and discriminatory properties and is therefore a valid instrument for PTSD measurements in clinical and research studies in Latvian military active service members and veterans.

The aim of the study was to determine the most effective medical treatment of patients with chronic pancreatitis, by using either pancreatin alone or in combination with proton pump inhibitor (PPI) or PPI and non-steroidal anti-inflammatory drug (NSAID). Patients with chronic pancreatitis, who did not require a surgical treatment, received medical treatment for a one–month period: 20 patients received pancreatin monotherapy; 48 patients were given a combination of pancreatin and PPI; 38 patients were treated with a combination of pancreatin, PPI and NSAID (PNP therapy group). In comparison with other groups, patients in the PNP therapy group showed improvement in body mass index, abdominal pain, bowel movements, chronic pancreatitis severity, as well as their quality of life assessment (p< 0.05). The combination of pancreatin, PPI and NSAID was the most effective among those applied in chronic pancreatitis patient treatment. A one–month long course of this therapy was safe and did not cause any significant adverse effects. The combination of pancreatin, PPI and NSAID for treatment of chronic pancreatitis can be recommended, as it is based on pathogenesis of the disease, effective, safe and economically advantageous.

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