Background/Objectives: The purpose of the study is to find out the factors affecting student readiness for education 4.0. Methods/Statistical analysis: Based on 361 samples, this quantitative research was conducted: reliability testing, exploratory factor analysis, correlation coefficients and linear regression. The result shows that there are four key factors affecting readiness including Self-regulation, Creativity, Upgrade and Attitude. Findings: The result of t-test shows that the group of students who had experienced online learning had higher readiness for the education 4.0 than the others. Improvements/Applications: The advantages that students realize when being involved in the 4.0 education system will help them greatly improve their skills and knowledge.