A method of blood flow measurement is described that determines flow through a particular artery in absolute units or as a fraction of the cardiac output. For measuring flow as a percentage of cardiac output, no assumption about the vessel's cross-sectional shape is necessary. If one assumes that the vessel's cross section is circular, then absolute flow determination is possible. All methods would require only a single intravenous injection of contrast material. Details of the theory of these methods are presented and alternative data analysis options are developed and discussed.

Temporal filtration of fluoroscopic video sequences is being used as an alternative to pulsed digital subtraction angiography. Using the same image processing architecture and a slight modification in processing logic a parametric image can be synthesized from such a temporally filtered image sequence in virtual real time, i.e., an image sequence that spans T seconds takes exactly T seconds to process. Off-line computer processing is not required. Initial phantom studies imply that the time to maximum opacification (tmax) can be used to determine absolute and relative blood flow with a high confidence level (r greater than .989). Phantom and animal examples are presented.

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