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Objectives: To assess the postnatal outcomes following prenatal ultrasound diagnosis of fetal abdominal cyst at our institution. Methods: We identified all fetal abdominal cysts diagnosed between 2005 and 2016 using our ultrasound database. The fetuses were monitored during the pregnancy to assess their antenatal course. Follow-up was continued during childhood to determine the postnatal diagnosis and outcome. Results: We found 80 cases of abdominal cysts. The antenatal diagnosis was thought to be of ovarian origin (n=45, 56%); intestinal origin (n=15, 18%); choledocal cysts (n=3, 4%), liver cysts (n=2, 3%) and renal/adrenal cysts (n=2, 3%). In 16% of cases the antenatal diagnosis was not obvious. Of presumed ovarian cysts, postnatal follow-up was available in 91% of cases and ovarian cyst was confirmed in 98% of cases. Of these, 68% resolved spontaneously; 7% required fetal intervention; 15% required surgery after birth; and the remaining 10% were managed conservatively. One suspected ovarian cyst was postnatally diagnosed as a mesenteric cyst. Of presumed intestinal cysts, postnatal follow-up was available in 73%. Of these 64% resolved spontaneously. The postnatal diagnosis was confirmed in 75%: enteric duplication cyst (50%) and mesenteric cyst (25%). Surgery was required in 1 out of 2 of duplication cysts that persisted postnatally. In one case the postnatal diagnosis was revised to bowel dilatation. Conclusions: Postnatal follow up of abdominal cysts is important in determining the outcome and allowing appropriate counselling. In our series, the antenatal detection of ovarian cysts was high and the outcome good, with 75% resolving and only 15% ultimately requiring surgery. Cysts with intestinal origin are more difficult to determine antenatally, although two thirds resolve spontaneously. EP12.35 Reliability of prenatal diagnosis on neonatal outcome in isolated left-sided congenital diaphragmatic hernia: the results of the perinatal centre in the years Objectives: Mortality in CDH patients remains high despite the introduction of new prenatal and postnatal diagnostic and therapeutic modalities. In isolated CDH survival chances can be predicted by antenatal measurement of lung size and liver herniation. Accurate prenatal diagnosis is essential for prognosis and potential treatment in utero. The aim was to evaluate the prenatal ultrasound findings in assessing survival rate and the respiratory prognosis in fetuses with isolated left-sided CDH. Methods: Neonatal mortality and morbidity was recorded in 59 cases of left-sided isolated CDH diagnosed prenatally in tertiary perinatal centre. Retrospective and regression analysis was used to identified significant predictors. Results: Survival rate in the study group was 73% (43/59). We found no statistically significant relationship between survival and the presence of polyhydramnios, gestational age at diagnosis, gestational age at birth and birth weight and also lung-to-head ratio (LHR) and observed/expected LHR (O/E LHR) values. Intrathoracic liver herniation was...

The finding that no donation studied was positive for p24 antigen and negative for HIV-1 antibody suggests that screening donors for p24 antigen with tests of the current level of sensitivity would not add substantially to the safety of the U.S. blood supply.

Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibiors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.