We compared the diagnostic capabilities of MRI to CT, evoked potentials (EP), and CSF oligoclonal banding analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). MRI was the best method for demonstrating dissemination in space. An abnormal appropriate EP in monosymptomatic disease was usually supported by MRI and CSF analysis as being predictive of MS as a clinical diagnosis. A normal appropriate EP study was not satisfactory because MRI and CSF analysis often did not support a diagnosis of non-MS. When there is agreement between three of these paraclinical studies, the diagnosis of MS is probably unequivocal. For use in research studies, laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200 (42.5%), in 19/38 (50%) of optic neuritis (ON) patients, and in 24/52 (46%) of chronic progressive myelopathy (CPM) patients. MRI was 100% successful in identifying patients who qualified for LSDMS in the ON and CPM groups. In a short follow-up (less than 1 year), 19/200 (10%) went on to develop clinically definite MS (CDMS), and MRI predicted that diagnosis in 18/19 (95%). Only long-term follow-up will show how well these studies and the category of LSDMS predict the development of CDMS. The clinical diagnosis of MS (CDMS), even though only 95% accurate, must remain the gold standard.

This study explores the use of multiple isotopic tracers to evaluate the processes involved in nitrate attenuation in ground water. δ15N and δ18O are used to provide information about the role of denitrification on nitrate attenuation, and δ34S, δ18O, and δ13C are used to evaluate the role of reduced sulfur and carbon as electron donors for nitrate reduction. The focus of this study is a zone of significant NO3−1 attenuation occurring in a sand aquifer impacted by septic system contamination. The NO3−1 pattern, the ground water flow system, and changes in other chemical parameters suggest that the NO3−1 depletion is caused by denitrification. This is supported by the nitrate δ15N and δ18O data which both show significant isotopic enrichment as NO3−1 depletion proceeds along the flow path. The increase of sulfate and dissolved inorganic carbon observed in the zone of nitrate attenuation suggests that reduced sulfur in addition to carbon is also involved in denitrification. This is supported by a trend toward depleted sulfate δ34S and δ18O values in the zone of sulfate increase, which reflects the input of sulfate formed by the oxidation of biogenic pyrite present in the aquifer sediments. The trend toward depleted δ13 values in the zone of increasing dissolved inorganic carbon reflects the input of organic carbon into this carbon pool. Chemical mass balance indicates that carbon is the dominant electron donor; however, this study demonstrates the effectiveness of using multiple isotopic tracers for providing insight into the processes affecting nitrate attenuation in ground water.

Sixty-eight patients with intraventricular hemorrhage (IVH) diagnosed by computed tomography (CT) were reviewed retrospectively to determine the etiology and prognosis, relationship to delayed hydrocephalus, and effect on neurological outcome. The most common causes were a ruptured aneurysm, trauma, and hypertensive hemorrhage. Ruptured aneurysms of the anterior communicating artery can often be predicted from the nonenhanced CT scan. The total mortality rate was 50%; however, 21% of patients returned to normal or had only mild disability. Patients in whom no cause was identified had a better prognosis. Delayed hydrocephalus was related to the effects of subarachnoid hemorrhage rather than obstruction of the ventricular system by blood. IVH per se is seldom a major factor in the neurological outcome.

Distinct plumes of septic system‐impacted ground water at two single‐family homes located on shallow unconfined sand aquifers in Ontario showed elevated levels of Cl−, NO3−, Na+, Ca2+, K+, alkalinity, and dissolved organic carbon and depressed levels of pH and dissolved oxygen. At the Cambridge site, in use 12 years, the plume had sharp lateral and vertical boundaries and was more than 130 m in length with a uniform width of about 10 m. As a result of low transverse dispersion in the aquifer, mobile plume solutes such as NO3− and Na+ occurred at more than 50 percent of the source concentrations 130 m downgradient from the septic system. At the Muskoka site, in use three years, the plume also had discrete boundaries reflecting low transverse dispersion. After 1.5 years of system operation, the Muskoka plume began discharging to a river located 20 m from the tile field. Almost complete NOs attenuation was observed within the last 2 m of the plume flowpath before discharge to the river. This was attributed to denitrification occurring within organic matter‐enriched riverbed sediments. The very weakly dispersive nature of the two aquifers was consistent with the results of recently reported natural‐gradient tracer tests in sands. Therefore, for many unconfined sand aquifers, the minimum distance‐to‐well regulations for permitting septic systems in most parts of North America should not be expected to be adequately protective of well‐water quality in situations where mobile contaminants such as NOs are not attenuated by chemical or microbiological processes.

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