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The fibrinogen circulating in plasma consists of three different fractions: high molecular weight fibrinogen (HMW Fb, MW 340 kD) and two low molecular weight fibrinogen fractions (LMW Fb, MW 305 kD and LMW' Fb, MW 270 kD).' The postoperative increase of total fibrinogen concentration is a known phenomenon and our investigations were aimed at the assessment of its fractions response to the surgery. MATERIAL AND METHODSPlasma samples were taken from 15 patients before and on days 1, 3, and 7 after surgery for renal cancer. The fibrin0 en concentration was measured spectrophotometrically at 280 and 315 nm (E f . ! , % 1.58).2 As a reference the standard of plasma fibrinogen from National Institute for Biological Standards and Controls (89/ 644) (Hedordshire, UK) was used. Fibrin fractions were separated by SDS electrophoresis on 5% acrylamide gel and scanned in a Pharmacia densitometer.3