Objective. To investigate the efficacy of oral type I1 collagen in the treatment of early rheumatoid arthritis (RA).Meth&. Ninety patients with RA (disease duration 5 3 years) were treated for 12 weeks with oral bovine type II collagen at 1 mglday (n = 30) or 10 mglday (n = 30) or with placebo (n = 30), in a double-blind randomized study.Results. There was no significant difference between the 3 groups in terms of response to treatment. However, we observed a higher prevalence of responders in the type I1 collagen-treated groups: 7 responders in the 10-mg type I1 collagen group and 6 in the l-mg group, versus 4 in the placebo group. Furthermore, 3 patients in the 10-mg type I1 collagen group and 1 patient in the 1-mg type I1 collagen group, but no patients in the placebo group, had very good response.

No abstract

No abstract

No abstract