The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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Effects of ethylenediaminetetraacetate (EDTA), citrate, ascorbate, succinate, and sorbitol on the absorption and postabsorptive distribution of Fe59Cl3 in the rat were studied, using an isolated loop technique. Citrate most effectively promoted iron absorption, with ascorbate, EDTA, and succinate following in that order. Sorbitol seemed without effect. Control animals with access to food until time of experiment absorbed more radioiron than did fasted controls. Partial trypsin hydrolysis permitted demonstration that succinate-exposed gut cells most avidly retained iron, while EDTA led to least cellular retention. Postabsorptive distribution among blood, liver, spleen, long bones, kidneys, and urine was unremarkable except that EDTA promoted marked radioiron urinary excretion. EDTA may pass through the gut wall as an intact iron chelate. A pattern of actions during iron absorption is proposed for EDTA, citrate, ascorbate, and succinate.

No abstract

Abstract— —A variety of monoamine oxidase substrates (tyramine, dopamine, serotonin, tryptamine) have been used with and without Iproniazid inhibition to evaluate further the extent to which enzyme multiplicity may exist in various regions of rat brain. Levels of monoamine oxidase activity, as measured by ammonia production, were found to vary as a function of both brain area and kind of substrate used, in the absence as well as in the presence of Iproniazid, in vivo and in vitro. Similarity of substrate metabolizing patterns among the different brain areas, however, strongly suggests that only one kind of monoamine oxidase exists in rat brain.