Abstract-This paper demonstrates a computer-aided diagnosis (CAD) system for lung cancer classification of CT scans with unmarked nodules, a dataset from the Kaggle Data Science Bowl, 2017. Thresholding was used as an initial segmentation approach to segment out lung tissue from the rest of the CT scan. Thresholding produced the next best lung segmentation. The initial approach was to directly feed the segmented CT scans into 3D CNNs for classification, but this proved to be inadequate. Instead, a modified U-Net trained on LUNA16 data (CT scans with labeled nodules) was used to first detect nodule candidates in the Kaggle CT scans. The U-Net nodule detection produced many false positives, so regions of CTs with segmented lungs where the most likely nodule candidates were located as determined by the U-Net output were fed into 3D Convolutional Neural Networks (CNNs) to ultimately classify the CT scan as positive or negative for lung cancer. The 3D CNNs produced a test set Accuracy of 86.6%. The performance of our CAD system outperforms the current CAD systems in literature which have several training and testing phases that each requires a lot of labeled data, while our CAD system has only three major phases (segmentation, nodule candidate detection, and malignancy classification), allowing more efficient training and detection and more generalizability to other cancers.

The COVID-19 pandemic has had a significant impact on public life and health worldwide, putting the world’s healthcare systems at risk. The first step in stopping this outbreak is to detect the infection in its early stages, which will relieve the risk, control the outbreak’s spread, and restore full functionality to the world’s healthcare systems. Currently, PCR is the most prevalent diagnosis tool for COVID-19. However, chest X-ray images may play an essential role in detecting this disease, as they are successful for many other viral pneumonia diseases. Unfortunately, there are common features between COVID-19 and other viral pneumonia, and hence manual differentiation between them seems to be a critical problem and needs the aid of artificial intelligence. This research employs deep- and transfer-learning techniques to develop accurate, general, and robust models for detecting COVID-19. The developed models utilize either convolutional neural networks or transfer-learning models or hybridize them with powerful machine-learning techniques to exploit their full potential. For experimentation, we applied the proposed models to two data sets: the COVID-19 Radiography Database from Kaggle and a local data set from Asir Hospital, Abha, Saudi Arabia. The proposed models achieved promising results in detecting COVID-19 cases and discriminating them from normal and other viral pneumonia with excellent accuracy. The hybrid models extracted features from the flatten layer or the first hidden layer of the neural network and then fed these features into a classification algorithm. This approach enhanced the results further to full accuracy for binary COVID-19 classification and 97.8% for multiclass classification.

The worldwide coronavirus (COVID-19) pandemic made dramatic and rapid progress in the year 2020 and requires urgent global effort to accelerate the development of a vaccine to stop the daily infections and deaths. Several types of vaccine have been designed to teach the immune system how to fight off certain kinds of pathogens. mRNA vaccines are the most important candidate vaccines because of their capacity for rapid development, high potency, safe administration and potential for low-cost manufacture. mRNA vaccine acts by training the body to recognize and response to the proteins produced by disease-causing organisms such as viruses or bacteria. This type of vaccine is the fastest candidate to treat COVID-19 but it currently facing several limitations. In particular, it is a challenge to design stable mRNA molecules because of the inefficient in vivo delivery of mRNA, its tendency for spontaneous degradation and low protein expression levels. This work designed and implemented a sequence deep model based on bidirectional GRU and LSTM models applied on the Stanford COVID-19 mRNA vaccine dataset to predict the mRNA sequences responsible for degradation by predicting five reactivity values for every position in the sequence. Four of these values determine the likelihood of degradation with/without magnesium at high pH (pH 10) and high temperature (50 degrees Celsius) and the fifth reactivity value is used to determine the likely secondary structure of the RNA sample. The model relies on two types of features, namely numerical and categorical features, where the categorical features are extracted from the mRNA sequences, structure and predicted loop. These features are represented and encoded by numbers, and then, the features are extracted using embedding layer learning. There are five numerical features depending on the likelihood for each pair of nucleotides in the RNA. The model gives promising results because it predicts the five reactivity values with a validation mean columnwise root mean square error (MCRMSE) of 0.125 using LSTM model with augmentation and the codon encoding method. Codon encoding outperforms Base encoding in MCRMSE validation error using the LSTM model meanwhile Base encoding outperforms codon encoding due to less over-fitting and the difference between the training and validation loss error is 0.008.

Abstract-The paper presents approaches for nodule detection and extraction in axial lung computed tomography. The goal is to detect correctly pulmonary nodule to recognize and screen lung cancer patients. The pulmonary nodule detection is very challenging problem. The proposed model developed a hybrid efficient model based on affine-invariant representation and shape of segmented nodule. Due to large number of extracted features for all slices on patient, feature selection is an important step to select the most important feature for classification. We apply forward stepwise least squares regression that maximizes the Rsquared value, this criterion provides a fast preprocessing feature selection assessment for systems with huge volumes of features based on a linear models framework. Moreover, gradient boosting have been suggested to select the relevant features based on boosting approach. Classification of patients has been done by support vector machine. Kaggle DSB dataset is used to test the accuracy of our model. The results show major improvement in accuracy and the features are reduced.