No abstract

The hydrocarbon squalene, which has been suggested as a precursor in the biosynthesis of cholesterol, was fed to rabbits to see whether cholesterol thus synthesized would be efficacious in producing atheromatous lesions. Rabbits on a 3 per cent squalene diet for seven weeks showed an increase in liver weight and liver nonsaponifiable material but no more atheroma than did controls. Animals on the same diet for 14 weeks showed an increase in the cholesterol-rich lipoproteins as determined in the ultracentrifuge. Addition of squalene in no way altered the atherogenic propensities of the cholesterol diet.

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The severity of atheromata in cholesterol-fed rabbits appears to vary inversely with the iodine number of the fat used as vehicle for the sterol. The serum cholesterol levels increase with increasing iodine number and the serum lipoprotein levels vary, depending on the class of lipoproteins being studied.

No abstract