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In livestock production, astragalus membranaceus (traditional Chinese herbal medicine) can improve its growth performance and antioxidant capacity, working as antioxidants to scavenge free radicals, and enhance the body's immunity and disease resistance. The advantages of Astragalus have no residue and side effects. In the previous studies, as a feed additive, the improvement of antioxidant capacity and meat quality of astragalus membranaceus are more common in pigs, chickens, geese, etc. But their application in goats has rarely been reported. Inner Mongolia Cashmere goats are excellent variety, which can offer cashmere and meat. Now, the research on Cashmere goat is mainly focused on cashmere performance, rumen metabolism, and

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To investigate the effects of the activator of AMPK and high glucose on the differentiation of mouse SMSCs, primary SMSCs were isolated from mouse extensor digitorum longus muscle and grown to near confluence (80%). Postconfluent cells were cultured in a growth medium with different inductors: AICAR, glucose, and AICAR mixed with glucose. The specific protein expressions of SMSCs, myoblasts, adipocytes, and brown adipocytes were analyzed on days 0, 3, 5, 7, and 10. The results showed treatment with AICAR in SMSCs markedly activated AMPK phosphorylation (p < .05) and increased protein expression of Pax7 and MyoD (p < .05), high concentrations of intracellular glucose upregulated UCP‐1 protein expression and enhanced lipid accumulation (p < .05), the cowork of AICAR and glucose affected a decrease on MyoD, PPARg, and UCP‐1 expression (p < .05) and an increase on Pax7. The present study indicated that the certain energy supplements influence the direction of SMSC differentiation which may contribution on the structure of muscle and meat quality, sequentially.