A kinetic resolution of racemic 2-substituted cyclopentanones via highly regio- and enantioselective Baeyer–Villiger oxidation has been successfully developed. The reaction could afford the normal 6-substituted δ-lactones in up to 98% ee and >19/1 regioselectivity. Meanwhile, the unreacted ketones were recovered in excellent ee values (up to 98%). It represents the best results of the kinetic resolution of racemic 2-substituted cyclopentanones via nonenzymic asymmetric BV oxidation.

A catalytic regio- and enantioselective haloazidation reaction with a chiral iron­(II) complex catalyst under mild reaction conditions was reported. By this approach, the stereoselective α-halo-β-azido difunctionalization of both α,β-unsaturated amides and α,β-unsaturated esters was achieved. This method enabled the construction of a broad spectrum of valuable functionalized amides and esters, including enantiomerically enriched β-azido amides, aziridine amides, α-amino amide derivatives, β-triazole amides, functionalized peptide derivatives, and α-halo-β-azido-substituted esters.

Ah ighly efficientc hiral N,N'-dioxidezinc(II) complexc atalytic system hasb een developed for the enantioselective aza-Friedel-Crafts reaction of isatin-derived ketimines with indoles. A series of enantiomerically enriched 3-indolyl-3-aminooxindoles containing at etrasubstituted stereocenter were obtained in up to 99% yield with up to 96% ee.F urthermore,c ontrol experiments provide afundamental sight into the mechanism of the reaction.

Classical kinetic resolution, parallel kinetic resolution and desymmetrization were achieved by asymmetric BV oxidation of 3-substituted and meso-disubstituted cycloketones.

An efficient diastereo- and enantioselective [3 + 2] cycloaddition of heterosubstituted alkenes with oxiranes via selective C-C bond cleavage of epoxides has been developed. The reaction was catalyzed by a chiral N,N'-dioxide/Ni(II) catalyst, and a variety of chiral highly substituted tetrahydrofurans were obtained in up to 99% yield, 92/8 dr, and 99% ee.