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An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety of polycyclic quinazolinones were successfully synthesized in 52-81% yields under transition metal-and oxidant-free conditions. The Langlois reagent used in this strategy as a CF 3 reagent possesses the advantages of bench-stablity, cost-effectivity and high-efficiency. Additionally, gram-scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol.

Organosulfurs are important commodity chemicals and indispensable synthetic intermediates in modern chemistry that traditionally synthesized using metal catalysts, oxidants or strong bases, which caused numerous issues of environment pollutions. The...

The development of electrochemical process method for the synthesis of P-chiral phosphine derivatives poses a considerable challenge. Here, we present an electricity-driven cobalt catalyzed enantioselective C–H annulation of arylphosphinic amides...