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One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (nirtetralin A), 16.7 µM (nirtetralin B) and 97.2 µM (nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (nirtetralin A), 69.3 µM (nirtetralin B) and 232.0 µM (nirtetralin), respectively.

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No abstract

The experimental data demonstrated that nirtetralin B exhibits anti-hepatitis B virus activity both in vitro and in vivo.