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Frailty is an age-related biological syndrome characterized by a decrease in physiological capacity and stress resistance as a result of a gradual decline in the body's physiological systems. Frailty syndrome is categorized into three categories: robust / fit, pre-frail, and frail. As a crucial aspect of immunosenescence, the presence of chronic "inflamm-aging" systemic inflammation characterizes aging. Proinflammatory cytokines, such as IL-6, increased in response to a rise in molecular inflammation as people got older. The goal of this study was to investigate the levels of IL-6 in older people dependent on their frailty status. Methods: This study used a cross-sectional design with 90 patients with frailty syndrome aged >=60 years who met the research requirements at Wahidin Sudirohusodo Hospital Makassar's Geriatric Polyclinic. The Cardiovascular Health Study (CHS) scoring system is used to assess frailty syndrome. The Anova and Kruskal-Wallis tests were used in the statistical analysis, and the results were considered significant if the p-value was less than 0.05. Results: Males made up the majority of the participants (54.4%), while females made up the rest (45.6 percent ). The most common form of weakness is frailty (43.3 percent ). Frail people had the highest levels of interleukin-6 (31.1213.40), compared to pre-frail people (22.503.29) and robust people (18.532.04). There was a statistically significant difference. Age >=70 years (27.019.02) and age 60-69 years (24.7110.94) had higher IL-6 levels. There was a statistically significant difference. Only at the age of 60-69 years did IL-6 levels change significantly between robust, pre-frail, and frail people. Conclusions: In subjects 60-69 years old, IL-6 levels increased in proportion to the severity of frailty. Interleukin-6 levels did not vary according to the severity of frailty status in population over the age of 70

Today, In Indonesia has been increased the number of life expectancy from the population of elderly in every year. For some research found that after the age of 60 years, mass of muscle and muscle strength decreases by up to 3% per year. The prevalence of sarcopenia is increasing. One of the causes of sarcopenia is vitamin D deficiency. This research aims to determine serum vitamin D levels from elderly: the relationship with the incidence and degree of sarcopenia. This cross-sectional research has conducted at Pos Pembinaan Terpadu Makassar with 107 elderly contributed during May until June 2021. SPSS ver. 25 was used in analyzing the data. From 107 subjects, 74.8% of women were dominated by old age. The maximum age is 60-69 years as much as 71%. Serum vitamin D levels were highest in

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